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Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype.
Nuechterlein N, Shelbourn A, Szulzewsky F, Arora S, Casad M, Pattwell S, Merino-Galan L, Sulman E, Arowa S, Alvinez N, Jung M, Brown D, Tang K, Jackson S, Stoica S, Chittaboina P, Banasavadi-Siddegowda YK, Wirsching HG, Stella N, Shapiro L, Paddison P, Patel AP, Gilbert MR, Abdullaev Z, Aldape K, Pratt D, Holland EC, Cimino PJ. Nuechterlein N, et al. Among authors: pratt d. Genes Dev. 2024 Apr 17;38(5-6):273-288. doi: 10.1101/gad.351350.123. Genes Dev. 2024. PMID: 38589034
Expanded analysis of high-grade astrocytoma with piloid features identifies an epigenetically and clinically distinct subtype associated with neurofibromatosis type 1.
Cimino PJ, Ketchum C, Turakulov R, Singh O, Abdullaev Z, Giannini C, Pytel P, Lopez GY, Colman H, Nasrallah MP, Santi M, Fernandes IL, Nirschl J, Dahiya S, Neill S, Solomon D, Perez E, Capper D, Mani H, Caccamo D, Ball M, Badruddoja M, Chkheidze R, Camelo-Piragua S, Fullmer J, Alexandrescu S, Yeaney G, Eberhart C, Martinez-Lage M, Chen J, Zach L, Kleinschmidt-DeMasters BK, Hefti M, Lopes MB, Nuechterlein N, Horbinski C, Rodriguez FJ, Quezado M, Pratt D, Aldape K. Cimino PJ, et al. Among authors: pratt d. Acta Neuropathol. 2023 Jan;145(1):71-82. doi: 10.1007/s00401-022-02513-5. Epub 2022 Oct 22. Acta Neuropathol. 2023. PMID: 36271929 Free PMC article.
A 64-year-old woman with frontal lobe lesion and drug-resistant epilepsy.
Jin X, Abdullaev Z, Butman JA, Inati SK, Rahman SA, Zaghloul KA, Papanicolau-Sengos A, Pratt DW, Aldape KD, Quezado MM. Jin X, et al. Among authors: pratt dw. Brain Pathol. 2023 Jan;33(1):e13133. doi: 10.1111/bpa.13133. Epub 2022 Dec 9. Brain Pathol. 2023. PMID: 36490308 Free PMC article. No abstract available.
High-grade glioma with pleomorphic and pseudopapillary features (HPAP): a proposed type of circumscribed glioma in adults harboring frequent TP53 mutations and recurrent monosomy 13.
Pratt D, Abdullaev Z, Papanicolau-Sengos A, Ketchum C, Panneer Selvam P, Chung HJ, Lee I, Raffeld M, Gilbert MR, Armstrong TS, Pytel P, Borys E, Klonoski JM, McCord M, Horbinski C, Brat D, Perry A, Solomon D, Eberhart C, Giannini C, Quezado M, Aldape K. Pratt D, et al. Acta Neuropathol. 2022 Mar;143(3):403-414. doi: 10.1007/s00401-022-02404-9. Epub 2022 Feb 1. Acta Neuropathol. 2022. PMID: 35103816 Free PMC article.
Molecular and clinicopathologic characteristics of CNS embryonal tumors with BRD4::LEUTX fusion.
Andreiuolo F, Ferrone CK, Rajan S, Perry A, Guney E, Cham E, Giannini C, Toland A, Willard N, de Souza AS, Dazelle K, Chung HJ, Singh O, Conway K, Coley N, Dampier C, Abdullaev Z, Pratt D, Cimino PJ, Quezado M, Aldape K. Andreiuolo F, et al. Among authors: pratt d. Acta Neuropathol Commun. 2024 Mar 18;12(1):42. doi: 10.1186/s40478-024-01746-7. Acta Neuropathol Commun. 2024. PMID: 38500181 Free PMC article.
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