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Cancer Cell Resistance Against the Clinically Investigated Thiosemicarbazone COTI-2 Is Based on Formation of Intracellular Copper Complex Glutathione Adducts and ABCC1-Mediated Efflux.
Bormio Nunes JH, Hager S, Mathuber M, Pósa V, Roller A, Enyedy ÉA, Stefanelli A, Berger W, Keppler BK, Heffeter P, Kowol CR. Bormio Nunes JH, et al. Among authors: kowol cr. J Med Chem. 2020 Nov 25;63(22):13719-13732. doi: 10.1021/acs.jmedchem.0c01277. Epub 2020 Nov 15. J Med Chem. 2020. PMID: 33190481 Free PMC article.
Paraptotic Cell Death as an Unprecedented Mode of Action Observed for New Bipyridine-Silver(I) Compounds Bearing Phosphane Coligands.
Teixeira RG, Stefanelli A, Pilon A, Warmers R, Fontrodona X, Romero I, Costa PJ, Villa de Brito MJ, Hudec X, Pirker C, Türck S, Antunes AMM, Kowol CR, Ott I, Brozovic A, Sombke A, Eckhard M, Tomaz AI, Heffeter P, Valente A. Teixeira RG, et al. Among authors: kowol cr. J Med Chem. 2024 Apr 25;67(8):6081-6098. doi: 10.1021/acs.jmedchem.3c01036. Epub 2024 Feb 24. J Med Chem. 2024. PMID: 38401050 Free PMC article.
Anticancer activity of metal complexes: involvement of redox processes.
Jungwirth U, Kowol CR, Keppler BK, Hartinger CG, Berger W, Heffeter P. Jungwirth U, et al. Among authors: kowol cr. Antioxid Redox Signal. 2011 Aug 15;15(4):1085-127. doi: 10.1089/ars.2010.3663. Epub 2011 May 11. Antioxid Redox Signal. 2011. PMID: 21275772 Free PMC article. Review.
Structure-Activity Relationships of Triple-Action Platinum(IV) Prodrugs with Albumin-Binding Properties and Immunomodulating Ligands.
Fronik P, Poetsch I, Kastner A, Mendrina T, Hager S, Hohenwallner K, Schueffl H, Herndler-Brandstetter D, Koellensperger G, Rampler E, Kopecka J, Riganti C, Berger W, Keppler BK, Heffeter P, Kowol CR. Fronik P, et al. Among authors: kowol cr. J Med Chem. 2021 Aug 26;64(16):12132-12151. doi: 10.1021/acs.jmedchem.1c00770. Epub 2021 Aug 17. J Med Chem. 2021. PMID: 34403254 Free PMC article.
85 results