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TDP2 is a regulator of estrogen-responsive oncogene expression.
Manguso N, Kim M, Joshi N, Al Mahmud MR, Aldaco J, Suzuki R, Cortes-Ledesma F, Cui X, Yamada S, Takeda S, Giuliano A, You S, Tanaka H. Manguso N, et al. Among authors: cortes ledesma f. NAR Cancer. 2024 Apr 8;6(2):zcae016. doi: 10.1093/narcan/zcae016. eCollection 2024 Jun. NAR Cancer. 2024. PMID: 38596431 Free PMC article.
Ubiquitin stimulated reversal of topoisomerase 2 DNA-protein crosslinks by TDP2.
Schellenberg MJ, Appel CD, Riccio AA, Butler LR, Krahn JM, Liebermann JA, Cortés-Ledesma F, Williams RS. Schellenberg MJ, et al. Among authors: cortes ledesma f. Nucleic Acids Res. 2020 Jun 19;48(11):6310-6325. doi: 10.1093/nar/gkaa318. Nucleic Acids Res. 2020. PMID: 32356875 Free PMC article.
Topological regulation of the estrogen transcriptional response by ZATT-mediated inhibition of TOP2B activity.
Terrón-Bautista J, Martínez-Sánchez MDM, López-Hernández L, Vadusevan AA, García-Domínguez M, Williams RS, Aguilera A, Millán-Zambrano G, Cortés-Ledesma F. Terrón-Bautista J, et al. Among authors: cortes ledesma f. bioRxiv [Preprint]. 2024 Jan 23:2024.01.22.576640. doi: 10.1101/2024.01.22.576640. bioRxiv. 2024. PMID: 38328138 Free PMC article. Preprint.
TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function.
Gómez-Herreros F, Schuurs-Hoeijmakers JH, McCormack M, Greally MT, Rulten S, Romero-Granados R, Counihan TJ, Chaila E, Conroy J, Ennis S, Delanty N, Cortés-Ledesma F, de Brouwer AP, Cavalleri GL, El-Khamisy SF, de Vries BB, Caldecott KW. Gómez-Herreros F, et al. Nat Genet. 2014 May;46(5):516-21. doi: 10.1038/ng.2929. Epub 2014 Mar 23. Nat Genet. 2014. PMID: 24658003
Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency.
Álvarez-Quilón A, Terrón-Bautista J, Delgado-Sainz I, Serrano-Benítez A, Romero-Granados R, Martínez-García PM, Jimeno-González S, Bernal-Lozano C, Quintero C, García-Quintanilla L, Cortés-Ledesma F. Álvarez-Quilón A, et al. Nat Commun. 2020 Feb 14;11(1):910. doi: 10.1038/s41467-020-14638-w. Nat Commun. 2020. PMID: 32060399 Free PMC article.
ZATT (ZNF451)-mediated resolution of topoisomerase 2 DNA-protein cross-links.
Schellenberg MJ, Lieberman JA, Herrero-Ruiz A, Butler LR, Williams JG, Muñoz-Cabello AM, Mueller GA, London RE, Cortés-Ledesma F, Williams RS. Schellenberg MJ, et al. Science. 2017 Sep 29;357(6358):1412-1416. doi: 10.1126/science.aam6468. Epub 2017 Sep 14. Science. 2017. PMID: 28912134 Free PMC article.
Topoisomerase IIα represses transcription by enforcing promoter-proximal pausing.
Herrero-Ruiz A, Martínez-García PM, Terrón-Bautista J, Millán-Zambrano G, Lieberman JA, Jimeno-González S, Cortés-Ledesma F. Herrero-Ruiz A, et al. Among authors: cortes ledesma f. Cell Rep. 2021 Apr 13;35(2):108977. doi: 10.1016/j.celrep.2021.108977. Cell Rep. 2021. PMID: 33852840 Free PMC article.
36 results