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ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D.
Du G, Healy LB, David L, Walker C, El-Baba TJ, Lutomski CA, Goh B, Gu B, Pi X, Devant P, Fontana P, Dong Y, Ma X, Miao R, Balasubramanian A, Puthenveetil R, Banerjee A, Luo HR, Kagan JC, Oh SF, Robinson CV, Lieberman J, Wu H. Du G, et al. Among authors: kagan jc. Nature. 2024 Apr 10. doi: 10.1038/s41586-024-07373-5. Online ahead of print. Nature. 2024. PMID: 38599239
Gasdermin D activity in inflammation and host defense.
Lieberman J, Wu H, Kagan JC. Lieberman J, et al. Among authors: kagan jc. Sci Immunol. 2019 Sep 6;4(39):eaav1447. doi: 10.1126/sciimmunol.aav1447. Sci Immunol. 2019. PMID: 31492708 Free PMC article. Review.
The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis.
Balasubramanian A, Hsu AY, Ghimire L, Tahir M, Devant P, Fontana P, Du G, Liu X, Fabin D, Kambara H, Xie X, Liu F, Hasegawa T, Xu R, Yu H, Chen M, Kolakowski S, Trauger S, Larsen MR, Wei W, Wu H, Kagan JC, Lieberman J, Luo HR. Balasubramanian A, et al. Among authors: kagan jc. Sci Immunol. 2024 Apr 12;9(94):eadn1452. doi: 10.1126/sciimmunol.adn1452. Epub 2024 Apr 12. Sci Immunol. 2024. PMID: 38530158
126 results