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mRNA-LNP vaccine-induced CD8+ T cells protect mice from lethal SARS-CoV-2 infection in the absence of specific antibodies.
Montoya B, Melo-Silva CR, Tang L, Kafle S, Lidskiy P, Bajusz C, Vadovics M, Muramatsu H, Abraham E, Lipinszki Z, Chatterjee D, Scher G, Benitez J, Sung MMH, Tam YK, Catanzaro NJ, Schäfer A, Andino R, Baric RS, Martinez DR, Pardi N, Sigal LJ. Montoya B, et al. Among authors: tang l. Mol Ther. 2024 Apr 11:S1525-0016(24)00236-3. doi: 10.1016/j.ymthe.2024.04.019. Online ahead of print. Mol Ther. 2024. PMID: 38605519 Free article.
Resistance to lethal ectromelia virus infection requires Type I interferon receptor in natural killer cells and monocytes but not in adaptive immune or parenchymal cells.
Melo-Silva CR, Alves-Peixoto P, Heath N, Tang L, Montoya B, Knudson CJ, Stotesbury C, Ferez M, Wong E, Sigal LJ. Melo-Silva CR, et al. Among authors: tang l. PLoS Pathog. 2021 May 20;17(5):e1009593. doi: 10.1371/journal.ppat.1009593. eCollection 2021 May. PLoS Pathog. 2021. PMID: 34015056 Free PMC article.
Mechanisms of Antiviral Cytotoxic CD4 T Cell Differentiation.
Knudson CJ, Férez M, Alves-Peixoto P, Erkes DA, Melo-Silva CR, Tang L, Snyder CM, Sigal LJ. Knudson CJ, et al. Among authors: tang l. J Virol. 2021 Sep 9;95(19):e0056621. doi: 10.1128/JVI.00566-21. Epub 2021 Jul 14. J Virol. 2021. PMID: 34260270 Free PMC article.
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