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Catharanthine Modulates Mesolimbic Dopamine Transmission and Nicotine Psychomotor Effects via Inhibition of α6-Nicotinic Receptors and Dopamine Transporters.
Williams BM, Steed ND, Woolley JT, Moedl AA, Nelson CA, Jones GC, Burris MD, Arias HR, Kim OH, Jang EY, Hone AJ, McIntosh JM, Yorgason JT, Steffensen SC. Williams BM, et al. Among authors: mcintosh jm. ACS Chem Neurosci. 2024 May 1;15(9):1738-1754. doi: 10.1021/acschemneuro.3c00478. Epub 2024 Apr 13. ACS Chem Neurosci. 2024. PMID: 38613458
Role of α6-Nicotinic Receptors in Alcohol-Induced GABAergic Synaptic Transmission and Plasticity to Cholinergic Interneurons in the Nucleus Accumbens.
Wadsworth HA, Anderson EQ, Williams BM, Ronström JW, Moen JK, Lee AM, McIntosh JM, Wu J, Yorgason JT, Steffensen SC. Wadsworth HA, et al. Among authors: mcintosh jm. Mol Neurobiol. 2023 Jun;60(6):3113-3129. doi: 10.1007/s12035-023-03263-5. Epub 2023 Feb 18. Mol Neurobiol. 2023. PMID: 36802012 Free PMC article.
Design, Synthesis, and Structure-Activity Relationships of Novel Peptide Derivatives of the Severe Acute Respiratory Syndrome-Coronavirus-2 Spike-Protein that Potently Inhibit Nicotinic Acetylcholine Receptors.
Hone AJ, Santiago U, Harvey PJ, Tekarli B, Gajewiak J, Craik DJ, Camacho CJ, McIntosh JM. Hone AJ, et al. Among authors: mcintosh jm. J Med Chem. 2024 May 30. doi: 10.1021/acs.jmedchem.4c00735. Online ahead of print. J Med Chem. 2024. PMID: 38814877
Aspartic acid mutagenesis of αO-Conotoxin GeXIVA isomers reveals arginine residues crucial for inhibition of the α9α10 nicotinic acetylcholine receptor.
Luo A, He J, Yu J, Wu Y, Harvey PJ, Kasheverov IE, Kudryavtsev DS, McIntosh JM, Tsetlin VI, Craik DJ, Zhangsun D, Luo S. Luo A, et al. Among authors: mcintosh jm. Int J Biol Macromol. 2024 May 19;271(Pt 1):132472. doi: 10.1016/j.ijbiomac.2024.132472. Online ahead of print. Int J Biol Macromol. 2024. PMID: 38772455
Differential tyrosine and serine/threonine phosphorylation/dephosphorylation pathways regulate the expression of α7 versus α3β4 nicotinic receptor subtypes in mouse hippocampal neurons.
Jiménez-Pompa A, Arribas RL, McIntosh JM, Albillos A. Jiménez-Pompa A, et al. Among authors: mcintosh jm. Biochem Biophys Res Commun. 2023 Dec 3;684:149115. doi: 10.1016/j.bbrc.2023.10.047. Epub 2023 Oct 13. Biochem Biophys Res Commun. 2023. PMID: 37879250 Free article.
Using Constellation Pharmacology to Characterize a Novel α-Conotoxin from Conus ateralbus.
Neves JLB, Urcino C, Chase K, Dowell C, Hone AJ, Morgenstern D, Chua VM, Ramiro IBL, Imperial JS, Leavitt LS, Phan J, Fisher FA, Watkins M, Raghuraman S, Tun JO, Ueberheide BM, McIntosh JM, Vasconcelos V, Olivera BM, Gajewiak J. Neves JLB, et al. Among authors: mcintosh jm. Mar Drugs. 2024 Feb 29;22(3):118. doi: 10.3390/md22030118. Mar Drugs. 2024. PMID: 38535458 Free PMC article.
DM506 (3-Methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole fumarate), a Novel Derivative of Ibogamine, Inhibits α7 and α9α10 Nicotinic Acetylcholine Receptors by Different Allosteric Mechanisms.
Tae HS, Ortells MO, Tekarli BJ, Manetti D, Romanelli MN, McIntosh JM, Adams DJ, Arias HR. Tae HS, et al. Among authors: mcintosh jm. ACS Chem Neurosci. 2023 Jul 19;14(14):2537-2547. doi: 10.1021/acschemneuro.3c00212. Epub 2023 Jun 29. ACS Chem Neurosci. 2023. PMID: 37386821
328 results