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Page 1
Molecular Pathophysiology of Cardiac Injury and Cardiac Microthrombi in Fatal COVID-19: Insights from Clinico-histopathologic and Single Nuclei RNA Sequencing Analyses.
Fukuma N, Hulke ML, Brener MI, Golob S, Zilinyi R, Zhou Z, Tzimas C, Russo I, McGroder C, Pfeiffer R, Chong A, Zhang G, Burkhoff D, Leon MB, Maurer M, Moses JW, Uhlemann AC, Hibshoosh H, Uriel N, Szabolcs MJ, Redfors B, Marboe CC, Baldwin MR, Tucker NR, Tsai EJ. Fukuma N, et al. Among authors: tzimas c. bioRxiv [Preprint]. 2021 Jul 27:2021.07.27.453843. doi: 10.1101/2021.07.27.453843. bioRxiv. 2021. PMID: 34341789 Free PMC article. Updated. Preprint.
A Novel Role for Phospholamban in the Thalamic Reticular Nucleus.
Klocke B, Britzolaki A, Saurine J, Ott H, Krone K, Bahamonde K, Thelen C, Tzimas C, Sanoudou D, Kranias EG, Pitychoutis PM. Klocke B, et al. Among authors: tzimas c. bioRxiv [Preprint]. 2023 Nov 23:2023.11.22.568306. doi: 10.1101/2023.11.22.568306. bioRxiv. 2023. PMID: 38045420 Free PMC article. Updated. Preprint.
A novel role for phospholamban in the thalamic reticular nucleus.
Klocke B, Britzolaki A, Saurine J, Ott H, Krone K, Bahamonde K, Thelen C, Tzimas C, Sanoudou D, Kranias EG, Pitychoutis PM. Klocke B, et al. Among authors: tzimas c. Sci Rep. 2024 Mar 16;14(1):6376. doi: 10.1038/s41598-024-56447-x. Sci Rep. 2024. PMID: 38493225 Free PMC article.
Clinico-histopathologic and single-nuclei RNA-sequencing insights into cardiac injury and microthrombi in critical COVID-19.
Brener MI, Hulke ML, Fukuma N, Golob S, Zilinyi RS, Zhou Z, Tzimas C, Russo I, McGroder C, Pfeiffer RD, Chong A, Zhang G, Burkhoff D, Leon MB, Maurer MS, Moses JW, Uhlemann AC, Hibshoosh H, Uriel N, Szabolcs MJ, Redfors B, Marboe CC, Baldwin MR, Tucker NR, Tsai EJ. Brener MI, et al. Among authors: tzimas c. JCI Insight. 2022 Jan 25;7(2):e154633. doi: 10.1172/jci.insight.154633. JCI Insight. 2022. PMID: 34905515 Free PMC article. Clinical Trial.
WIPI1 is a conserved mediator of right ventricular failure.
Tzimas C, Rau CD, Buergisser PE, Jean-Louis G Jr, Lee K, Chukwuneke J, Dun W, Wang Y, Tsai EJ. Tzimas C, et al. JCI Insight. 2019 Apr 25;5(11):e122929. doi: 10.1172/jci.insight.122929. JCI Insight. 2019. PMID: 31021818 Free PMC article.
Impaired calcium homeostasis is associated with sudden cardiac death and arrhythmias in a genetic equivalent mouse model of the human HRC-Ser96Ala variant.
Tzimas C, Johnson DM, Santiago DJ, Vafiadaki E, Arvanitis DA, Davos CH, Varela A, Athanasiadis NC, Dimitriou C, Katsimpoulas M, Sonntag S, Kryzhanovska M, Shmerling D, Lehnart SE, Sipido KR, Kranias EG, Sanoudou D. Tzimas C, et al. Cardiovasc Res. 2017 Sep 1;113(11):1403-1417. doi: 10.1093/cvr/cvx113. Cardiovasc Res. 2017. PMID: 28859293
Notch Represses Transcription by PRC2 Recruitment to the Ternary Complex.
Han X, Ranganathan P, Tzimas C, Weaver KL, Jin K, Astudillo L, Zhou W, Zhu X, Li B, Robbins DJ, Capobianco AJ. Han X, et al. Among authors: tzimas c. Mol Cancer Res. 2017 Sep;15(9):1173-1183. doi: 10.1158/1541-7786.MCR-17-0241. Epub 2017 Jun 5. Mol Cancer Res. 2017. PMID: 28584023 Free PMC article.
Correction of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy.
Karakikes I, Stillitano F, Nonnenmacher M, Tzimas C, Sanoudou D, Termglinchan V, Kong CW, Rushing S, Hansen J, Ceholski D, Kolokathis F, Kremastinos D, Katoulis A, Ren L, Cohen N, Gho JMIH, Tsiapras D, Vink A, Wu JC, Asselbergs FW, Li RA, Hulot JS, Kranias EG, Hajjar RJ. Karakikes I, et al. Among authors: tzimas c. Nat Commun. 2015 Apr 29;6:6955. doi: 10.1038/ncomms7955. Nat Commun. 2015. PMID: 25923014 Free PMC article.
Cardioprotection by H2S engages a cGMP-dependent protein kinase G/phospholamban pathway.
Bibli SI, Andreadou I, Chatzianastasiou A, Tzimas C, Sanoudou D, Kranias E, Brouckaert P, Coletta C, Szabo C, Kremastinos DT, Iliodromitis EK, Papapetropoulos A. Bibli SI, et al. Among authors: tzimas c. Cardiovasc Res. 2015 Jun 1;106(3):432-42. doi: 10.1093/cvr/cvv129. Epub 2015 Apr 13. Cardiovasc Res. 2015. PMID: 25870184 Free PMC article.
17 results