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CD200 is overexpressed in the pancreatic tumor microenvironment and predictive of overall survival.
Wedig J, Jasani S, Mukherjee D, Lathrop H, Matreja P, Pfau T, D'Alesio L, Guenther A, Fenn L, Kaiser M, Torok MA, McGue J, Sizemore GM, Noonan AM, Dillhoff ME, Blaser BW, Frankel TL, Culp S, Hart PA, Cruz-Monserrate Z, Mace TA. Wedig J, et al. Among authors: frankel tl. Cancer Immunol Immunother. 2024 Apr 15;73(6):96. doi: 10.1007/s00262-024-03678-6. Cancer Immunol Immunother. 2024. PMID: 38619621 Free PMC article.
Tomatidine targets ATF4-dependent signaling and induces ferroptosis to limit pancreatic cancer progression.
Mukherjee D, Chakraborty S, Bercz L, D'Alesio L, Wedig J, Torok MA, Pfau T, Lathrop H, Jasani S, Guenther A, McGue J, Adu-Ampratwum D, Fuchs JR, Frankel TL, Pietrzak M, Culp S, Strohecker AM, Skardal A, Mace TA. Mukherjee D, et al. Among authors: frankel tl. iScience. 2023 Jul 17;26(8):107408. doi: 10.1016/j.isci.2023.107408. eCollection 2023 Aug 18. iScience. 2023. PMID: 37554459 Free PMC article.
Analysis of Donor Pancreata Defines the Transcriptomic Signature and Microenvironment of Early Neoplastic Lesions.
Carpenter ES, Elhossiny AM, Kadiyala P, Li J, McGue J, Griffith BD, Zhang Y, Edwards J, Nelson S, Lima F, Donahue KL, Du W, Bischoff AC, Alomari D, Watkoske HR, Mattea M, The S, Espinoza CE, Barrett M, Sonnenday CJ, Olden N, Chen CT, Peterson N, Gunchick V, Sahai V, Rao A, Bednar F, Shi J, Frankel TL, Pasca di Magliano M. Carpenter ES, et al. Among authors: frankel tl. Cancer Discov. 2023 Jun 2;13(6):1324-1345. doi: 10.1158/2159-8290.CD-23-0013. Cancer Discov. 2023. PMID: 37021392 Free PMC article.
Multimodal Mapping of the Tumor and Peripheral Blood Immune Landscape in Human Pancreatic Cancer.
Steele NG, Carpenter ES, Kemp SB, Sirihorachai VR, The S, Delrosario L, Lazarus J, Amir ED, Gunchick V, Espinoza C, Bell S, Harris L, Lima F, Irizarry-Negron V, Paglia D, Macchia J, Chu AKY, Schofield H, Wamsteker EJ, Kwon R, Schulman A, Prabhu A, Law R, Sondhi A, Yu J, Patel A, Donahue K, Nathan H, Cho C, Anderson MA, Sahai V, Lyssiotis CA, Zou W, Allen BL, Rao A, Crawford HC, Bednar F, Frankel TL, Pasca di Magliano M. Steele NG, et al. Among authors: frankel tl. Nat Cancer. 2020 Nov;1(11):1097-1112. doi: 10.1038/s43018-020-00121-4. Epub 2020 Oct 26. Nat Cancer. 2020. PMID: 34296197 Free PMC article.
Regulatory T-cell Depletion Alters the Tumor Microenvironment and Accelerates Pancreatic Carcinogenesis.
Zhang Y, Lazarus J, Steele NG, Yan W, Lee HJ, Nwosu ZC, Halbrook CJ, Menjivar RE, Kemp SB, Sirihorachai VR, Velez-Delgado A, Donahue K, Carpenter ES, Brown KL, Irizarry-Negron V, Nevison AC, Vinta A, Anderson MA, Crawford HC, Lyssiotis CA, Frankel TL, Bednar F, Pasca di Magliano M. Zhang Y, et al. Among authors: frankel tl. Cancer Discov. 2020 Mar;10(3):422-439. doi: 10.1158/2159-8290.CD-19-0958. Epub 2020 Jan 7. Cancer Discov. 2020. PMID: 31911451 Free PMC article.
Extrinsic KRAS Signaling Shapes the Pancreatic Microenvironment Through Fibroblast Reprogramming.
Velez-Delgado A, Donahue KL, Brown KL, Du W, Irizarry-Negron V, Menjivar RE, Lasse Opsahl EL, Steele NG, The S, Lazarus J, Sirihorachai VR, Yan W, Kemp SB, Kerk SA, Bollampally M, Yang S, Scales MK, Avritt FR, Lima F, Lyssiotis CA, Rao A, Crawford HC, Bednar F, Frankel TL, Allen BL, Zhang Y, Pasca di Magliano M. Velez-Delgado A, et al. Among authors: frankel tl. Cell Mol Gastroenterol Hepatol. 2022;13(6):1673-1699. doi: 10.1016/j.jcmgh.2022.02.016. Epub 2022 Mar 1. Cell Mol Gastroenterol Hepatol. 2022. PMID: 35245687 Free PMC article.
Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early pre-neoplastic pancreatic lesions.
Carpenter ES, Elhossiny AM, Kadiyala P, Li J, McGue J, Griffith B, Zhang Y, Edwards J, Nelson S, Lima F, Donahue KL, Du W, Bischoff AC, Alomari D, Watkoske H, Mattea M, The S, Espinoza C, Barrett M, Sonnenday CJ, Olden N, Peterson N, Gunchick V, Sahai V, Rao A, Bednar F, Shi J, Frankel TL, Di Magliano MP. Carpenter ES, et al. Among authors: frankel tl. bioRxiv [Preprint]. 2023 Jan 15:2023.01.13.523300. doi: 10.1101/2023.01.13.523300. bioRxiv. 2023. PMID: 36712058 Free PMC article. Updated. Preprint.
93 results