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Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons.
Al-Dalahmah O, Lam M, McInvale JJ, Qu W, Nguyen T, Mun JY, Kwon S, Ifediora N, Mahajan A, Humala N, Winters T, Angeles E, Jakubiak KA, Kühn R, Kim YA, De Rosa MC, Doege CA, Paryani F, Flowers X, Dovas A, Mela A, Lu H, DeTure MA, Vonsattel JP, Wszolek ZK, Dickson DW, Kuhlmann T, Zaehres H, Schöler HR, Sproul AA, Siegelin MD, De Jager PL, Goldman JE, Menon V, Canoll P, Hargus G. Al-Dalahmah O, et al. Among authors: doege ca. Cell Stem Cell. 2024 May 2;31(5):676-693.e10. doi: 10.1016/j.stem.2024.03.013. Epub 2024 Apr 15. Cell Stem Cell. 2024. PMID: 38626772 Free article.
DMSO increases efficiency of genome editing at two non-coding loci.
Stratigopoulos G, De Rosa MC, LeDuc CA, Leibel RL, Doege CA. Stratigopoulos G, et al. Among authors: doege ca. PLoS One. 2018 Jun 4;13(6):e0198637. doi: 10.1371/journal.pone.0198637. eCollection 2018. PLoS One. 2018. PMID: 29864154 Free PMC article.
Bardet-Biedl syndrome proteins regulate intracellular signaling and neuronal function in patient-specific iPSC-derived neurons.
Wang L, Liu Y, Stratigopoulos G, Panigrahi S, Sui L, Zhang Y, Leduc CA, Glover HJ, De Rosa MC, Burnett LC, Williams DJ, Shang L, Goland R, Tsang SH, Wardlaw S, Egli D, Zheng D, Doege CA, Leibel RL. Wang L, et al. Among authors: doege ca. J Clin Invest. 2021 Apr 15;131(8):e146287. doi: 10.1172/JCI146287. J Clin Invest. 2021. PMID: 33630762 Free PMC article.
Gene expression atlas of energy balance brain regions.
De Rosa MC, Glover HJ, Stratigopoulos G, LeDuc CA, Su Q, Shen Y, Sleeman MW, Chung WK, Leibel RL, Altarejos JY, Doege CA. De Rosa MC, et al. Among authors: doege ca. JCI Insight. 2021 Aug 23;6(16):e149137. doi: 10.1172/jci.insight.149137. JCI Insight. 2021. PMID: 34283813 Free PMC article.
Ciliary gene RPGRIP1L is required for hypothalamic arcuate neuron development.
Wang L, De Solis AJ, Goffer Y, Birkenbach KE, Engle SE, Tanis R, Levenson JM, Li X, Rausch R, Purohit M, Lee JY, Tan J, De Rosa MC, Doege CA, Aaron HL, Martins GJ, Brüning JC, Egli D, Costa R, Berbari N, Leibel RL, Stratigopoulos G. Wang L, et al. Among authors: doege ca. JCI Insight. 2019 Feb 7;4(3):e123337. doi: 10.1172/jci.insight.123337. JCI Insight. 2019. PMID: 30728336 Free PMC article.
Dementia in a dish.
Doege CA, Abeliovich A. Doege CA, et al. Biol Psychiatry. 2014 Apr 1;75(7):558-64. doi: 10.1016/j.biopsych.2014.01.007. Epub 2014 Jan 27. Biol Psychiatry. 2014. PMID: 24629668 Review.
Characterization of Rare Variants in MC4R in African American and Latino Children With Severe Early-Onset Obesity.
De Rosa MC, Chesi A, McCormack S, Zhou J, Weaver B, McDonald M, Christensen S, Liimatta K, Rosenbaum M, Hakonarson H, Doege CA, Grant SFA, Hirschhorn JN, Thaker VV. De Rosa MC, et al. Among authors: doege ca. J Clin Endocrinol Metab. 2019 Jul 1;104(7):2961-2970. doi: 10.1210/jc.2018-02657. J Clin Endocrinol Metab. 2019. PMID: 30811542 Free PMC article.
Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits.
Pahl MC, Doege CA, Hodge KM, Littleton SH, Leonard ME, Lu S, Rausch R, Pippin JA, De Rosa MC, Basak A, Bradfield JP, Hammond RK, Boehm K, Berkowitz RI, Lasconi C, Su C, Chesi A, Johnson ME, Wells AD, Voight BF, Leibel RL, Cousminer DL, Grant SFA. Pahl MC, et al. Among authors: doege ca. Nat Commun. 2021 Nov 19;12(1):6749. doi: 10.1038/s41467-021-27001-4. Nat Commun. 2021. PMID: 34799566 Free PMC article.
27 results