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Placental senescence pathophysiology is shared between peripartum cardiomyopathy and preeclampsia in mouse and human.
Roh JD, Castro C, Yu A, Rana S, Shahul S, Gray KJ, Honigberg MC, Ricke-Hoch M, Iwamoto Y, Yeri A, Kitchen R, Guerra JB, Hobson R, Chaudhari V, Chang B, Sarma A, Lerchenmüller C, Al Sayed ZR, Diaz Verdugo C, Xia P, Skarbianskis N, Zeisel A, Bauersachs J, Kirkland JL, Karumanchi SA, Gorcsan J 3rd, Sugahara M, Damp J, Hanley-Yanez K, Ellinor PT, Arany Z, McNamara DM; IPAC Investigators; Hilfiker-Kleiner D, Rosenzweig A. Roh JD, et al. Among authors: kirkland jl. Sci Transl Med. 2024 Apr 17;16(743):eadi0077. doi: 10.1126/scitranslmed.adi0077. Epub 2024 Apr 17. Sci Transl Med. 2024. PMID: 38630848
Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia.
Suvakov S, Cubro H, White WM, Butler Tobah YS, Weissgerber TL, Jordan KL, Zhu XY, Woollard JR, Chebib FT, Milic NM, Grande JP, Xu M, Tchkonia T, Kirkland JL, Lerman LO, Garovic VD. Suvakov S, et al. Among authors: kirkland jl. Biol Sex Differ. 2019 Sep 14;10(1):49. doi: 10.1186/s13293-019-0263-5. Biol Sex Differ. 2019. PMID: 31521202 Free PMC article.
Cellular senescence and senolytics: the path to the clinic.
Chaib S, Tchkonia T, Kirkland JL. Chaib S, et al. Among authors: kirkland jl. Nat Med. 2022 Aug;28(8):1556-1568. doi: 10.1038/s41591-022-01923-y. Epub 2022 Aug 11. Nat Med. 2022. PMID: 35953721 Free PMC article. Review.
Obesity, Senescence, and Senolytics.
Chaib S, Tchkonia T, Kirkland JL. Chaib S, et al. Among authors: kirkland jl. Handb Exp Pharmacol. 2022;274:165-180. doi: 10.1007/164_2021_555. Handb Exp Pharmacol. 2022. PMID: 34697668
Mechanisms of vascular dysfunction in the interleukin-10-deficient murine model of preeclampsia indicate nitric oxide dysregulation.
Cubro H, Nath KA, Suvakov S, Garcia-Valencia O, Parashuram S, White WM, Weissgerber TL, Nath MC, Milic NM, Sontag F, d'Uscio LV, Zhu Y, Kirkland JL, Tchkonia T, Alexander MP, Quinton RA, Katusic ZS, Grande JP, Garovic VD. Cubro H, et al. Among authors: kirkland jl. Kidney Int. 2021 Mar;99(3):646-656. doi: 10.1016/j.kint.2020.09.034. Epub 2020 Nov 2. Kidney Int. 2021. PMID: 33144212 Free PMC article.
Targeting cellular senescence in metabolic disease.
Palmer AK, Tchkonia T, Kirkland JL. Palmer AK, et al. Among authors: kirkland jl. Mol Metab. 2022 Dec;66:101601. doi: 10.1016/j.molmet.2022.101601. Epub 2022 Sep 16. Mol Metab. 2022. PMID: 36116755 Free PMC article. Review.
353 results