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Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes.
Nat Hum Behav. 2024 Apr 17. doi: 10.1038/s41562-024-01851-6. Online ahead of print.
Nat Hum Behav. 2024.
PMID: 38632388
Multi-ancestry meta-analysis of tobacco use disorder prioritizes novel candidate risk genes and reveals associations with numerous health outcomes.
Toikumo S, Jennings MV, Pham BK, Lee H, Mallard TT, Bianchi SB, Meredith JJ, Vilar-Ribó L, Xu H, Hatoum AS, Johnson EC, Pazdernik V, Jinwala Z, Pakala SR, Leger BS, Niarchou M, Ehinmowo M; Penn Medicine BioBank, Million Veteran Program, PsycheMERGE Substance Use Disorder Workgroup; Jenkins GD, Batzler A, Pendegraft R, Palmer AA, Zhou H, Biernacka JM, Coombes BJ, Gelernter J, Xu K, Hancock DB, Cox NJ, Smoller JW, Davis LK, Justice AC, Kranzler HR, Kember RL, Sanchez-Roige S.
Toikumo S, et al. Among authors: leger bs.
medRxiv [Preprint]. 2023 Sep 18:2023.03.27.23287713. doi: 10.1101/2023.03.27.23287713.
medRxiv. 2023.
PMID: 37034728
Free PMC article.
Updated.
Preprint.
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Rare and Common Variants Associated with Alcohol Consumption Identify a Conserved Molecular Network.
Leger BS, Meredith JJ, Ideker T, Sanchez-Roige S, Palmer AA.
Leger BS, et al.
bioRxiv [Preprint]. 2024 Mar 1:2024.02.26.582195. doi: 10.1101/2024.02.26.582195.
bioRxiv. 2024.
PMID: 38464225
Free PMC article.
Preprint.
Item in Clipboard
Genome-wide association studies of human and rat BMI converge on synapse, epigenome, and hormone signaling networks.
Wright SN, Leger BS, Rosenthal SB, Liu SN, Jia T, Chitre AS, Polesskaya O, Holl K, Gao J, Cheng R, Garcia Martinez A, George A, Gileta AF, Han W, Netzley AH, King CP, Lamparelli A, Martin C, St Pierre CL, Wang T, Bimschleger H, Richards J, Ishiwari K, Chen H, Flagel SB, Meyer P, Robinson TE, Solberg Woods LC, Kreisberg JF, Ideker T, Palmer AA.
Wright SN, et al. Among authors: leger bs.
Cell Rep. 2023 Aug 29;42(8):112873. doi: 10.1016/j.celrep.2023.112873. Epub 2023 Jul 31.
Cell Rep. 2023.
PMID: 37527041
Free PMC article.
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Htt is a repressor of Abl activity required for APP-induced axonal growth.
Marquilly C, Busto GU, Leger BS, Boulanger A, Giniger E, Walker JA, Fradkin LG, Dura JM.
Marquilly C, et al. Among authors: leger bs.
PLoS Genet. 2021 Jan 19;17(1):e1009287. doi: 10.1371/journal.pgen.1009287. eCollection 2021 Jan.
PLoS Genet. 2021.
PMID: 33465062
Free PMC article.
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Chemogenetic System Demonstrates That Cas9 Longevity Impacts Genome Editing Outcomes.
Sreekanth V, Zhou Q, Kokkonda P, Bermudez-Cabrera HC, Lim D, Law BK, Holmes BR, Chaudhary SK, Pergu R, Leger BS, Walker JA, Gifford DK, Sherwood RI, Choudhary A.
Sreekanth V, et al. Among authors: leger bs.
ACS Cent Sci. 2020 Dec 23;6(12):2228-2237. doi: 10.1021/acscentsci.0c00129. Epub 2020 Nov 18.
ACS Cent Sci. 2020.
PMID: 33376784
Free PMC article.
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Small-Molecule Control of Super-Mendelian Inheritance in Gene Drives.
López Del Amo V, Leger BS, Cox KJ, Gill S, Bishop AL, Scanlon GD, Walker JA, Gantz VM, Choudhary A.
López Del Amo V, et al. Among authors: leger bs.
Cell Rep. 2020 Jun 30;31(13):107841. doi: 10.1016/j.celrep.2020.107841.
Cell Rep. 2020.
PMID: 32610142
Free PMC article.
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