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Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning.
Nat Chem Biol. 2024 May;20(5):634-645. doi: 10.1038/s41589-024-01580-x. Epub 2024 Apr 17.
Nat Chem Biol. 2024.
PMID: 38632492
Free PMC article.
The Hsc70 disaggregation machinery removes monomer units directly from α-synuclein fibril ends.
Schneider MM, Gautam S, Herling TW, Andrzejewska E, Krainer G, Miller AM, Trinkaus VA, Peter QAE, Ruggeri FS, Vendruscolo M, Bracher A, Dobson CM, Hartl FU, Knowles TPJ.
Schneider MM, et al.
Nat Commun. 2021 Oct 14;12(1):5999. doi: 10.1038/s41467-021-25966-w.
Nat Commun. 2021.
PMID: 34650037
Free PMC article.
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Design of amyloidogenic peptide traps.
Sahtoe DD, Andrzejewska EA, Han HL, Rennella E, Schneider MM, Meisl G, Ahlrichs M, Decarreau J, Nguyen H, Kang A, Levine P, Lamb M, Li X, Bera AK, Kay LE, Knowles TPJ, Baker D.
Sahtoe DD, et al. Among authors: andrzejewska ea.
Nat Chem Biol. 2024 Mar 19. doi: 10.1038/s41589-024-01578-5. Online ahead of print.
Nat Chem Biol. 2024.
PMID: 38503834
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Aβ Oligomer Dissociation Is Catalyzed by Fibril Surfaces.
Dear AJ, Thacker D, Wennmalm S, Ortigosa-Pascual L, Andrzejewska EA, Meisl G, Linse S, Knowles TPJ.
Dear AJ, et al. Among authors: andrzejewska ea.
ACS Chem Neurosci. 2024 May 24. doi: 10.1021/acschemneuro.4c00127. Online ahead of print.
ACS Chem Neurosci. 2024.
PMID: 38785363
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