Knowles TPJ - Search Results

1

Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning.

Horne RI, Andrzejewska EA, Alam P, Brotzakis ZF, Srivastava A, Aubert A, Nowinska M, Gregory RC, Staats R, Possenti A, Chia S, Sormanni P, Ghetti B, Caughey B, Knowles TPJ, Vendruscolo M. Horne RI, et al. Among authors: knowles tpj. Nat Chem Biol. 2024 May;20(5):634-645. doi: 10.1038/s41589-024-01580-x. Epub 2024 Apr 17. Nat Chem Biol. 2024. PMID: 38632492 Free PMC article.

2

Characterisation of amyloid fibril formation by small heat-shock chaperone proteins human alphaA-, alphaB- and R120G alphaB-crystallins.

Meehan S, Knowles TP, Baldwin AJ, Smith JF, Squires AM, Clements P, Treweek TM, Ecroyd H, Tartaglia GG, Vendruscolo M, Macphee CE, Dobson CM, Carver JA. Meehan S, et al. J Mol Biol. 2007 Sep 14;372(2):470-84. doi: 10.1016/j.jmb.2007.06.060. Epub 2007 Jun 29. J Mol Biol. 2007. PMID: 17662998

3

Position-dependent electrostatic protection against protein aggregation.

Buell AK, Tartaglia GG, Birkett NR, Waudby CA, Vendruscolo M, Salvatella X, Welland ME, Dobson CM, Knowles TP. Buell AK, et al. Chembiochem. 2009 May 25;10(8):1309-12. doi: 10.1002/cbic.200900144. Chembiochem. 2009. PMID: 19415709

4

Metastability of native proteins and the phenomenon of amyloid formation.

Baldwin AJ, Knowles TP, Tartaglia GG, Fitzpatrick AW, Devlin GL, Shammas SL, Waudby CA, Mossuto MF, Meehan S, Gras SL, Christodoulou J, Anthony-Cahill SJ, Barker PD, Vendruscolo M, Dobson CM. Baldwin AJ, et al. J Am Chem Soc. 2011 Sep 14;133(36):14160-3. doi: 10.1021/ja2017703. Epub 2011 Aug 19. J Am Chem Soc. 2011. PMID: 21650202

5

Protein solubility and protein homeostasis: a generic view of protein misfolding disorders.

Vendruscolo M, Knowles TP, Dobson CM. Vendruscolo M, et al. Cold Spring Harb Perspect Biol. 2011 Dec 1;3(12):a010454. doi: 10.1101/cshperspect.a010454. Cold Spring Harb Perspect Biol. 2011. PMID: 21825020 Free PMC article. Review.

6

Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments.

Cohen SI, Vendruscolo M, Welland ME, Dobson CM, Terentjev EM, Knowles TP. Cohen SI, et al. J Chem Phys. 2011 Aug 14;135(6):065105. doi: 10.1063/1.3608916. J Chem Phys. 2011. PMID: 21842954 Free PMC article.

7

Nucleated polymerization with secondary pathways. II. Determination of self-consistent solutions to growth processes described by non-linear master equations.

Cohen SI, Vendruscolo M, Dobson CM, Knowles TP. Cohen SI, et al. J Chem Phys. 2011 Aug 14;135(6):065106. doi: 10.1063/1.3608917. J Chem Phys. 2011. PMID: 21842955 Free PMC article.

8

Nucleated polymerization with secondary pathways. III. Equilibrium behavior and oligomer populations.

Cohen SI, Vendruscolo M, Dobson CM, Knowles TP. Cohen SI, et al. J Chem Phys. 2011 Aug 14;135(6):065107. doi: 10.1063/1.3608918. J Chem Phys. 2011. PMID: 21842956 Free PMC article.

9

Nucleated polymerisation in the presence of pre-formed seed filaments.

Cohen SI, Vendruscolo M, Dobson CM, Knowles TP. Cohen SI, et al. Int J Mol Sci. 2011;12(9):5844-52. doi: 10.3390/ijms12095844. Epub 2011 Sep 9. Int J Mol Sci. 2011. PMID: 22016630 Free PMC article.

10

Inversion of the balance between hydrophobic and hydrogen bonding interactions in protein folding and aggregation.

Fitzpatrick AW, Knowles TP, Waudby CA, Vendruscolo M, Dobson CM. Fitzpatrick AW, et al. PLoS Comput Biol. 2011 Oct;7(10):e1002169. doi: 10.1371/journal.pcbi.1002169. Epub 2011 Oct 13. PLoS Comput Biol. 2011. PMID: 22022239 Free PMC article.

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