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Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning.
Horne RI, Andrzejewska EA, Alam P, Brotzakis ZF, Srivastava A, Aubert A, Nowinska M, Gregory RC, Staats R, Possenti A, Chia S, Sormanni P, Ghetti B, Caughey B, Knowles TPJ, Vendruscolo M. Horne RI, et al. Among authors: vendruscolo m. Nat Chem Biol. 2024 May;20(5):634-645. doi: 10.1038/s41589-024-01580-x. Epub 2024 Apr 17. Nat Chem Biol. 2024. PMID: 38632492 Free PMC article.
Characterisation of amyloid fibril formation by small heat-shock chaperone proteins human alphaA-, alphaB- and R120G alphaB-crystallins.
Meehan S, Knowles TP, Baldwin AJ, Smith JF, Squires AM, Clements P, Treweek TM, Ecroyd H, Tartaglia GG, Vendruscolo M, Macphee CE, Dobson CM, Carver JA. Meehan S, et al. Among authors: vendruscolo m. J Mol Biol. 2007 Sep 14;372(2):470-84. doi: 10.1016/j.jmb.2007.06.060. Epub 2007 Jun 29. J Mol Biol. 2007. PMID: 17662998
Position-dependent electrostatic protection against protein aggregation.
Buell AK, Tartaglia GG, Birkett NR, Waudby CA, Vendruscolo M, Salvatella X, Welland ME, Dobson CM, Knowles TP. Buell AK, et al. Among authors: vendruscolo m. Chembiochem. 2009 May 25;10(8):1309-12. doi: 10.1002/cbic.200900144. Chembiochem. 2009. PMID: 19415709
An analytical solution to the kinetics of breakable filament assembly.
Knowles TP, Waudby CA, Devlin GL, Cohen SI, Aguzzi A, Vendruscolo M, Terentjev EM, Welland ME, Dobson CM. Knowles TP, et al. Among authors: vendruscolo m. Science. 2009 Dec 11;326(5959):1533-7. doi: 10.1126/science.1178250. Science. 2009. PMID: 20007899
Metastability of native proteins and the phenomenon of amyloid formation.
Baldwin AJ, Knowles TP, Tartaglia GG, Fitzpatrick AW, Devlin GL, Shammas SL, Waudby CA, Mossuto MF, Meehan S, Gras SL, Christodoulou J, Anthony-Cahill SJ, Barker PD, Vendruscolo M, Dobson CM. Baldwin AJ, et al. Among authors: vendruscolo m. J Am Chem Soc. 2011 Sep 14;133(36):14160-3. doi: 10.1021/ja2017703. Epub 2011 Aug 19. J Am Chem Soc. 2011. PMID: 21650202
522 results