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Overexpression of Fibroblast Activation Protein (FAP) in stroma of proliferative inflammatory atrophy (PIA) and primary adenocarcinoma of the prostate.
Caramella-Pereira F, Zheng Q, Hicks JL, Roy S, Jones T, Pomper M, Antony L, Meeker AK, Yegnasubramanian S, De Marzo AM, Brennen WN. Caramella-Pereira F, et al. Among authors: brennen wn. medRxiv [Preprint]. 2024 Apr 5:2024.04.04.24305338. doi: 10.1101/2024.04.04.24305338. medRxiv. 2024. PMID: 38633791 Free PMC article. Preprint.
Characterization of structural, biochemical, pharmacokinetic, and pharmacodynamic properties of the LSD1 inhibitor bomedemstat in preclinical models.
Jasmine S, Mandl A, Krueger TEG, Dalrymple SL, Antony L, Dias J, Celatka CA, Tapper AE, Kleppe M, Kanayama M, Jing Y, Speranzini V, Wang YZ, Luo J, Trock BJ, Denmeade SR, Carducci MA, Mattevi A, Rienhoff HY Jr, Isaacs JT, Brennen WN. Jasmine S, et al. Among authors: brennen wn. Prostate. 2024 Jul;84(10):909-921. doi: 10.1002/pros.24707. Epub 2024 Apr 15. Prostate. 2024. PMID: 38619005
Prostate fibroblasts and prostate cancer associated fibroblasts exhibit different metabolic, matrix degradation and PD-L1 expression responses to hypoxia.
Pacheco-Torres J, Sharma RK, Mironchik Y, Wildes F, Brennen WN, Artemov D, Krishnamachary B, Bhujwalla ZM. Pacheco-Torres J, et al. Among authors: brennen wn. Front Mol Biosci. 2024 Mar 22;11:1354076. doi: 10.3389/fmolb.2024.1354076. eCollection 2024. Front Mol Biosci. 2024. PMID: 38584702 Free PMC article.
The Hallmarks of Precancer.
Stangis MM, Chen Z, Min J, Glass SE, Jackson JO, Radyk MD, Hoi XP, Brennen WN, Yu M, Dinh HQ, Coffey RJ, Shrubsole MJ, Chan KS, Grady WM, Yegnasubramanian S, Lyssiotis CA, Maitra A, Halberg RB, Dey N, Lau KS. Stangis MM, et al. Among authors: brennen wn. Cancer Discov. 2024 Apr 4;14(4):683-689. doi: 10.1158/2159-8290.CD-23-1550. Cancer Discov. 2024. PMID: 38571435
Defining the challenges and opportunities for using patient-derived models in prostate cancer research.
Brennen WN, Le Magnen C, Karkampouna S, Anselmino N, Bock N, Choo N, Clark AK, Coleman IM, Dolgos R, Ferguson AM, Goode DL, Krutihof-de Julio M, Navone NM, Nelson PS, O'Neill E, Porter LH, Ranasinghe W, Sunada T, Williams ED, Butler LM, Corey E, van Weerden WM, Taylor RA, Risbridger GP, Lawrence MG. Brennen WN, et al. Prostate. 2024 May;84(7):623-635. doi: 10.1002/pros.24682. Epub 2024 Mar 7. Prostate. 2024. PMID: 38450798 Free article. Review.
LSD1 inhibition suppresses ASCL1 and de-represses YAP1 to drive potent activity against neuroendocrine prostate cancer.
Mandl A, Jasmine S, Krueger T, Kumar R, Coleman IM, Dalrymple SL, Antony L, Rosen DM, Jing Y, Hanratty B, Patel RA, Jin-Yih L, Dias J, Celatka CA, Tapper AE, Kleppe M, Kanayama M, Speranzini V, Wang YZ, Luo J, Corey E, Sena LA, Casero RA, Lotan T, Trock BJ, Kachhap SK, Denmeade SR, Carducci MA, Mattevi A, Haffner MC, Nelson PS, Rienhoff HY, Isaacs JT, Brennen WN. Mandl A, et al. Among authors: brennen wn. bioRxiv [Preprint]. 2024 Jan 22:2024.01.17.576106. doi: 10.1101/2024.01.17.576106. bioRxiv. 2024. PMID: 38328141 Free PMC article. Preprint.
Prognostic and therapeutic potential of senescent stromal fibroblasts in prostate cancer.
Mori JO, Elhussin I, Brennen WN, Graham MK, Lotan TL, Yates CC, De Marzo AM, Denmeade SR, Yegnasubramanian S, Nelson WG, Denis GV, Platz EA, Meeker AK, Heaphy CM. Mori JO, et al. Among authors: brennen wn. Nat Rev Urol. 2024 May;21(5):258-273. doi: 10.1038/s41585-023-00827-x. Epub 2023 Oct 31. Nat Rev Urol. 2024. PMID: 37907729 Review.
Characterization of HOXB13 expression patterns in localized and metastatic castration-resistant prostate cancer.
Patel RA, Sayar E, Coleman I, Roudier MP, Hanratty B, Low JY, Jaiswal N, Ajkunic A, Dumpit R, Ercan C, Salama N, O'Brien VP, Isaacs WB, Epstein JI, De Marzo AM, Trock BJ, Luo J, Brennen WN, Tretiakova M, Vakar-Lopez F, True LD, Goodrich DW, Corey E, Morrissey C, Nelson PS, Hurley PJ, Gulati R, Haffner MC. Patel RA, et al. Among authors: brennen wn. J Pathol. 2024 Jan;262(1):105-120. doi: 10.1002/path.6216. Epub 2023 Oct 18. J Pathol. 2024. PMID: 37850574
Third generation quinoline-3-carboxamide transcriptional disrupter of HDAC4, HIF-1α, and MEF-2 signaling for metastatic castration-resistant prostate cancer.
Isaacs JT, Dalrymple SL, Antony L, Marc Rosen D, Coleman IM, Nelson PS, Kostova M, Murray IA, Perdew GH, Denmeade SR, Akinboye ES, Brennen WN. Isaacs JT, et al. Among authors: brennen wn. Prostate. 2023 Nov;83(15):1470-1493. doi: 10.1002/pros.24606. Epub 2023 Aug 9. Prostate. 2023. PMID: 37559436
62 results