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Biomarker Predictors of Clinical Efficacy of the Anti-IgE Biologic, Omalizumab, in Severe Asthma in Adults: Results of the SoMOSA Study.
Djukanović R, Brinkman P, Kolmert J, Gomez C, Schofield J, Brandsma J, Shapanis A, Skipp PJS, Postle A, Wheelock C, Dahlén SE, Sterk PJ, Brown T, Jackson DJ, Mansur A, Pavord I, Patel M, Brightling C, Siddiqui S, Bradding P, Sabroe I, Saralaya D, Chishimba L, Porter J, Robinson D, Fowler SJ, Howarth PH, Little L, Oliver T, Hill K, Stanton L, Allen A, Ellis D, Griffiths G, Harrison T, Akenroye A, Lasky-Su J, Heaney L, Chaudhuri R, Kurukulaaratchy R. Djukanović R, et al. Among authors: schofield j. Am J Respir Crit Care Med. 2024 Apr 18. doi: 10.1164/rccm.202310-1730OC. Online ahead of print. Am J Respir Crit Care Med. 2024. PMID: 38635834
A Severe Asthma Disease Signature from Gene Expression Profiling of Peripheral Blood from U-BIOPRED Cohorts.
Bigler J, Boedigheimer M, Schofield JPR, Skipp PJ, Corfield J, Rowe A, Sousa AR, Timour M, Twehues L, Hu X, Roberts G, Welcher AA, Yu W, Lefaudeux D, Meulder B, Auffray C, Chung KF, Adcock IM, Sterk PJ, Djukanović R; U-BIOPRED Study Group ‖. Bigler J, et al. Among authors: schofield jpr. Am J Respir Crit Care Med. 2017 May 15;195(10):1311-1320. doi: 10.1164/rccm.201604-0866OC. Am J Respir Crit Care Med. 2017. PMID: 27925796 Free article.
Validated and longitudinally stable asthma phenotypes based on cluster analysis of the ADEPT study.
Loza MJ, Djukanovic R, Chung KF, Horowitz D, Ma K, Branigan P, Barnathan ES, Susulic VS, Silkoff PE, Sterk PJ, Baribaud F; ADEPT (Airways Disease Endotyping for Personalized Therapeutics) and U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease Outcome Consortium) investigators. Loza MJ, et al. Respir Res. 2016 Dec 15;17(1):165. doi: 10.1186/s12931-016-0482-9. Respir Res. 2016. PMID: 27978840 Free PMC article.
Urinary Leukotriene E4 and Prostaglandin D2 Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type 2 Inflammation. A Clinical Observational Study.
Kolmert J, Gómez C, Balgoma D, Sjödin M, Bood J, Konradsen JR, Ericsson M, Thörngren JO, James A, Mikus M, Sousa AR, Riley JH, Bates S, Bakke PS, Pandis I, Caruso M, Chanez P, Fowler SJ, Geiser T, Howarth P, Horváth I, Krug N, Montuschi P, Sanak M, Behndig A, Shaw DE, Knowles RG, Holweg CTJ, Wheelock ÅM, Dahlén B, Nordlund B, Alving K, Hedlin G, Chung KF, Adcock IM, Sterk PJ, Djukanovic R, Dahlén SE, Wheelock CE; U-BIOPRED Study Group, on behalf of the U-BIOPRED Study Group. Kolmert J, et al. Am J Respir Crit Care Med. 2021 Jan 1;203(1):37-53. doi: 10.1164/rccm.201909-1869OC. Am J Respir Crit Care Med. 2021. PMID: 32667261 Free PMC article.
U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics.
Lefaudeux D, De Meulder B, Loza MJ, Peffer N, Rowe A, Baribaud F, Bansal AT, Lutter R, Sousa AR, Corfield J, Pandis I, Bakke PS, Caruso M, Chanez P, Dahlén SE, Fleming LJ, Fowler SJ, Horvath I, Krug N, Montuschi P, Sanak M, Sandstrom T, Shaw DE, Singer F, Sterk PJ, Roberts G, Adcock IM, Djukanovic R, Auffray C, Chung KF; U-BIOPRED Study Group. Lefaudeux D, et al. J Allergy Clin Immunol. 2017 Jun;139(6):1797-1807. doi: 10.1016/j.jaci.2016.08.048. Epub 2016 Oct 20. J Allergy Clin Immunol. 2017. PMID: 27773852 Free article.
The role of inflammation in anxiety and depression in the European U-BIOPRED asthma cohorts.
Hou R, Ye G, Cheng X, Shaw DE, Bakke PS, Caruso M, Dahlen B, Dahlen SE, Fowler SJ, Horváth I, Howarth P, Krug N, Montuschi P, Sanak M, Sandström T, Auffray C, De Meulder B, Sousa AR, Adcock IM, Fan Chung K, Sterk PJ, Skipp PJ, Schofield J, Djukanović R; U-BIOPRED Study Group. Hou R, et al. Among authors: schofield j. Brain Behav Immun. 2023 Jul;111:249-258. doi: 10.1016/j.bbi.2023.04.011. Epub 2023 May 3. Brain Behav Immun. 2023. PMID: 37146653 Free article.
Epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux.
Perotin JM, Schofield JPR, Wilson SJ, Ward J, Brandsma J, Strazzeri F, Bansal A, Yang X, Rowe A, Corfield J, Lutter R, Shaw DE, Bakke PS, Caruso M, Dahlén B, Fowler SJ, Horváth I, Howarth P, Krug N, Montuschi P, Sanak M, Sandström T, Sun K, Pandis I, Auffray C, De Meulder B, Lefaudeux D, Riley JH, Sousa AR, Dahlen SE, Adcock IM, Chung KF, Sterk PJ, Skipp PJ, Collins JE, Davies DE, Djukanović R; U-BIOPRED Study Group; U-BIOPRED:. Perotin JM, et al. Among authors: schofield jpr. Eur Respir J. 2019 Jun 27;53(6):1900453. doi: 10.1183/13993003.00453-2019. Print 2019 Jun. Eur Respir J. 2019. PMID: 31023846 Free PMC article. No abstract available.
Vulnerability to acid reflux of the airway epithelium in severe asthma.
Perotin JM, Wheway G, Tariq K, Azim A, Ridley RA, Ward JA, Schofield JPR, Barber C, Howarth P, Davies DE, Djukanovic R. Perotin JM, et al. Eur Respir J. 2022 Aug 4;60(2):2101634. doi: 10.1183/13993003.01634-2021. Print 2022 Aug. Eur Respir J. 2022. PMID: 34996831 Free article.
Stratification of asthma by lipidomic profiling of induced sputum supernatant.
Brandsma J, Schofield JPR, Yang X, Strazzeri F, Barber C, Goss VM, Koster G, Bakke PS, Caruso M, Chanez P, Dahlén SE, Fowler SJ, Horváth I, Krug N, Montuschi P, Sanak M, Sandström T, Shaw DE, Chung KF, Singer F, Fleming LJ, Adcock IM, Pandis I, Bansal AT, Corfield J, Sousa AR, Sterk PJ, Sánchez-García RJ, Skipp PJ, Postle AD, Djukanović R; U-BIOPRED Study Group. Brandsma J, et al. Among authors: schofield jpr. J Allergy Clin Immunol. 2023 Jul;152(1):117-125. doi: 10.1016/j.jaci.2023.02.032. Epub 2023 Mar 12. J Allergy Clin Immunol. 2023. PMID: 36918039 Free article.
Stratification of asthma phenotypes by airway proteomic signatures.
Schofield JPR, Burg D, Nicholas B, Strazzeri F, Brandsma J, Staykova D, Folisi C, Bansal AT, Xian Y, Guo Y, Rowe A, Corfield J, Wilson S, Ward J, Lutter R, Shaw DE, Bakke PS, Caruso M, Dahlen SE, Fowler SJ, Horváth I, Howarth P, Krug N, Montuschi P, Sanak M, Sandström T, Sun K, Pandis I, Riley J, Auffray C, De Meulder B, Lefaudeux D, Sousa AR, Adcock IM, Chung KF, Sterk PJ, Skipp PJ, Djukanović R; U-BIOPRED Study Group. Schofield JPR, et al. J Allergy Clin Immunol. 2019 Jul;144(1):70-82. doi: 10.1016/j.jaci.2019.03.013. Epub 2019 Mar 28. J Allergy Clin Immunol. 2019. PMID: 30928653 Free article.
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