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Antibodies targeting the shared cytokine receptor IL-1 receptor accessory protein invoke distinct mechanisms to block all cytokine signaling.
Fields JK, Gyllenbäck EJ, Bogacz M, Obi J, Birkedal GS, Sjöström K, Maravillas K, Grönberg C, Rattik S, Kihn K, Flowers M, Smith AK, Hansen N, Fioretos T, Huyhn C, Liberg D, Deredge D, Sundberg EJ. Fields JK, et al. Among authors: deredge d. Cell Rep. 2024 Apr 11:114099. doi: 10.1016/j.celrep.2024.114099. Online ahead of print. Cell Rep. 2024. PMID: 38636519 Free article.
The structure of NAD+ consuming protein Acinetobacter baumannii TIR domain shows unique kinetics and conformations.
Klontz E, Obi JO, Wang Y, Glendening G, Carr J, Tsibouris C, Buddula S, Nallar S, Soares AS, Beckett D, Redzic JS, Eisenmesser E, Palm C, Schmidt K, Scudder AH, Obiorah T, Essuman K, Milbrandt J, Diantonio A, Ray K, Snyder MLD, Deredge D, Snyder GA. Klontz E, et al. Among authors: deredge d. J Biol Chem. 2023 Nov;299(11):105290. doi: 10.1016/j.jbc.2023.105290. Epub 2023 Sep 25. J Biol Chem. 2023. PMID: 37758001 Free PMC article.
Development and characterization of nanobodies that specifically target the oncogenic Phosphatase of Regenerating Liver-3 (PRL-3) and impact its interaction with a known binding partner, CNNM3.
Smith CN, Kihn K, Williamson ZA, Chow KM, Hersh LB, Korotkov KV, Deredge D, Blackburn JS. Smith CN, et al. Among authors: deredge d. PLoS One. 2023 May 23;18(5):e0285964. doi: 10.1371/journal.pone.0285964. eCollection 2023. PLoS One. 2023. PMID: 37220097 Free PMC article.
Mechanism of antibody-specific deglycosylation and immune evasion by Streptococcal IgG-specific endoglycosidases.
Trastoy B, Du JJ, Cifuente JO, Rudolph L, García-Alija M, Klontz EH, Deredge D, Sultana N, Huynh CG, Flowers MW, Li C, Sastre DE, Wang LX, Corzana F, Mallagaray A, Sundberg EJ, Guerin ME. Trastoy B, et al. Among authors: deredge d. Nat Commun. 2023 Mar 27;14(1):1705. doi: 10.1038/s41467-023-37215-3. Nat Commun. 2023. PMID: 36973249 Free PMC article.
Characterization of interaction between blood coagulation factor VIII and LRP1 suggests dynamic binding by alternating complex contacts.
Chun H, Kurasawa JH, Olivares P, Marakasova ES, Shestopal SA, Hassink GU, Karnaukhova E, Migliorini M, Obi JO, Smith AK, Wintrode PL, Durai P, Park K, Deredge D, Strickland DK, Sarafanov AG. Chun H, et al. Among authors: deredge d. J Thromb Haemost. 2022 Oct;20(10):2255-2269. doi: 10.1111/jth.15817. Epub 2022 Aug 4. J Thromb Haemost. 2022. PMID: 35810466 Free PMC article.
41 results