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In utero and postnatal ivacaftor/lumacaftor therapy rescues multiorgan disease in CFTR-F508del ferrets.
Evans IA, Sun X, Liang B, Vegter AR, Guo L, Lynch TJ, Zhang Y, Zhang Y, Yi Y, Yang Y, Feng Z, Park SY, Shonka A, McCumber H, Qi L, Wu P, Liu G, Lacina A, Wang K, Gibson-Corley KN, Meyerholz DK, Limoli DH, Rosen BH, Yan Z, Bartels DJ, Engelhardt JF. Evans IA, et al. Among authors: lynch tj. JCI Insight. 2024 Apr 22;9(8):e157229. doi: 10.1172/jci.insight.157229. JCI Insight. 2024. PMID: 38646935 Free article.
Gastrointestinal pathology in juvenile and adult CFTR-knockout ferrets.
Sun X, Olivier AK, Yi Y, Pope CE, Hayden HS, Liang B, Sui H, Zhou W, Hager KR, Zhang Y, Liu X, Yan Z, Fisher JT, Keiser NW, Song Y, Tyler SR, Goeken JA, Kinyon JM, Radey MC, Fligg D, Wang X, Xie W, Lynch TJ, Kaminsky PM, Brittnacher MJ, Miller SI, Parekh K, Meyerholz DK, Hoffman LR, Frana T, Stewart ZA, Engelhardt JF. Sun X, et al. Among authors: lynch tj. Am J Pathol. 2014 May;184(5):1309-22. doi: 10.1016/j.ajpath.2014.01.035. Epub 2014 Mar 15. Am J Pathol. 2014. PMID: 24637292 Free PMC article.
Lung phenotype of juvenile and adult cystic fibrosis transmembrane conductance regulator-knockout ferrets.
Sun X, Olivier AK, Liang B, Yi Y, Sui H, Evans TI, Zhang Y, Zhou W, Tyler SR, Fisher JT, Keiser NW, Liu X, Yan Z, Song Y, Goeken JA, Kinyon JM, Fligg D, Wang X, Xie W, Lynch TJ, Kaminsky PM, Stewart ZA, Pope RM, Frana T, Meyerholz DK, Parekh K, Engelhardt JF. Sun X, et al. Among authors: lynch tj. Am J Respir Cell Mol Biol. 2014 Mar;50(3):502-12. doi: 10.1165/rcmb.2013-0261OC. Am J Respir Cell Mol Biol. 2014. PMID: 24074402 Free PMC article.
Detargeting Lentiviral-Mediated CFTR Expression in Airway Basal Cells Using miR-106b.
Choi SH, Reeves RE, Romano Ibarra GS, Lynch TJ, Shahin WS, Feng Z, Gasser GN, Winter MC, Evans TIA, Liu X, Luo M, Zhang Y, Stoltz DA, Devor EJ, Yan Z, Engelhardt JF. Choi SH, et al. Among authors: lynch tj. Genes (Basel). 2020 Oct 6;11(10):1169. doi: 10.3390/genes11101169. Genes (Basel). 2020. PMID: 33036232 Free PMC article.
AAV-mediated gene editing lights up the lung.
Yan Z, Lynch TJ, Engelhardt JF. Yan Z, et al. Among authors: lynch tj. Mol Ther. 2022 Jan 5;30(1):7-9. doi: 10.1016/j.ymthe.2021.12.003. Epub 2021 Dec 10. Mol Ther. 2022. PMID: 34895514 Free PMC article. No abstract available.
353 results