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Tyrosine phosphorylation of CARM1 promotes its enzymatic activity and alters its target specificity.
Itonaga H, Mookhtiar AK, Greenblatt SM, Liu F, Martinez C, Bilbao D, Rains M, Hamard PJ, Sun J, Umeano AC, Duffort S, Chen C, Man N, Mas G, Tottone L, Totiger T, Bradley T, Taylor J, Schürer S, Nimer SD. Itonaga H, et al. Among authors: nimer sd. Nat Commun. 2024 Apr 22;15(1):3415. doi: 10.1038/s41467-024-47689-4. Nat Commun. 2024. PMID: 38649367 Free PMC article.
TAF1 plays a critical role in AML1-ETO driven leukemogenesis.
Xu Y, Man N, Karl D, Martinez C, Liu F, Sun J, Martinez CJ, Martin GM, Beckedorff F, Lai F, Yue J, Roisman A, Greenblatt S, Duffort S, Wang L, Sun X, Figueroa M, Shiekhattar R, Nimer S. Xu Y, et al. Nat Commun. 2019 Oct 29;10(1):4925. doi: 10.1038/s41467-019-12735-z. Nat Commun. 2019. PMID: 31664040 Free PMC article.
PARP inhibitors: a treatment option for AML?
Wang L, Hamard PJ, Nimer SD. Wang L, et al. Among authors: nimer sd. Nat Med. 2015 Dec;21(12):1393-4. doi: 10.1038/nm.4007. Nat Med. 2015. PMID: 26646494 No abstract available.
CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis.
Greenblatt SM, Man N, Hamard PJ, Asai T, Karl D, Martinez C, Bilbao D, Stathias V, Jermakowicz AM, Duffort S, Tadi M, Blumenthal E, Newman S, Vu L, Xu Y, Liu F, Schurer SC, McCabe MT, Kruger RG, Xu M, Yang FC, Tenen DG, Watts J, Vega F, Nimer SD. Greenblatt SM, et al. Among authors: nimer sd. Cancer Cell. 2018 Jun 11;33(6):1111-1127.e5. doi: 10.1016/j.ccell.2018.05.007. Cancer Cell. 2018. PMID: 29894694 Free PMC article.
Loss of Asxl2 leads to myeloid malignancies in mice.
Li J, He F, Zhang P, Chen S, Shi H, Sun Y, Guo Y, Yang H, Man N, Greenblatt S, Li Z, Guo Z, Zhou Y, Wang L, Morey L, Williams S, Chen X, Wang QT, Nimer SD, Yu P, Wang QF, Xu M, Yang FC. Li J, et al. Among authors: nimer sd. Nat Commun. 2017 Jun 8;8:15456. doi: 10.1038/ncomms15456. Nat Commun. 2017. PMID: 28593990 Free PMC article.
258 results