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Tyrosine phosphorylation of CARM1 promotes its enzymatic activity and alters its target specificity.
Itonaga H, Mookhtiar AK, Greenblatt SM, Liu F, Martinez C, Bilbao D, Rains M, Hamard PJ, Sun J, Umeano AC, Duffort S, Chen C, Man N, Mas G, Tottone L, Totiger T, Bradley T, Taylor J, Schürer S, Nimer SD. Itonaga H, et al. Among authors: schurer s. Nat Commun. 2024 Apr 22;15(1):3415. doi: 10.1038/s41467-024-47689-4. Nat Commun. 2024. PMID: 38649367 Free PMC article.
CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis.
Greenblatt SM, Man N, Hamard PJ, Asai T, Karl D, Martinez C, Bilbao D, Stathias V, Jermakowicz AM, Duffort S, Tadi M, Blumenthal E, Newman S, Vu L, Xu Y, Liu F, Schurer SC, McCabe MT, Kruger RG, Xu M, Yang FC, Tenen DG, Watts J, Vega F, Nimer SD. Greenblatt SM, et al. Among authors: schurer sc. Cancer Cell. 2018 Jun 11;33(6):1111-1127.e5. doi: 10.1016/j.ccell.2018.05.007. Cancer Cell. 2018. PMID: 29894694 Free PMC article.
Drug Repositioning in Glioblastoma: A Pathway Perspective.
Tan SK, Jermakowicz A, Mookhtiar AK, Nemeroff CB, Schürer SC, Ayad NG. Tan SK, et al. Front Pharmacol. 2018 Mar 16;9:218. doi: 10.3389/fphar.2018.00218. eCollection 2018. Front Pharmacol. 2018. PMID: 29615902 Free PMC article. Review.
CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis.
Greenblatt SM, Man N, Hamard PJ, Asai T, Karl D, Martinez C, Bilbao D, Stathias V, Jermakowicz AM, Duffort S, Tadi M, Blumenthal E, Newman S, Vu L, Xu Y, Liu F, Schurer SC, McCabe MT, Kruger RG, Xu M, Yang FC, Tenen DG, Watts J, Vega F, Nimer SD. Greenblatt SM, et al. Among authors: schurer sc. Cancer Cell. 2019 Jan 14;35(1):156. doi: 10.1016/j.ccell.2018.12.008. Cancer Cell. 2019. PMID: 30645972 Free article. No abstract available.
CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis.
Greenblatt SM, Man N, Hamard PJ, Asai T, Karl D, Martinez C, Bilbao D, Stathias V, McGrew-Jermacowicz A, Duffort S, Tadi M, Blumenthal E, Newman S, Vu L, Xu Y, Liu F, Schurer SC, McCabe MT, Kruger RG, Xu M, Yang FC, Tenen D, Watts J, Vega F, Nimer SD. Greenblatt SM, et al. Among authors: schurer sc. Cancer Cell. 2018 Nov 12;34(5):868. doi: 10.1016/j.ccell.2018.10.009. Cancer Cell. 2018. PMID: 30423301 Free PMC article. No abstract available.
Identification of DOT1L inhibitors by structure-based virtual screening adapted from a nucleoside-focused library.
Gibbons GS, Chakraborty A, Grigsby SM, Umeano AC, Liao C, Moukha-Chafiq O, Pathak V, Mathew B, Lee YT, Dou Y, Schürer SC, Reynolds RC, Snowden TS, Nikolovska-Coleska Z. Gibbons GS, et al. Among authors: schurer sc. Eur J Med Chem. 2020 Mar 1;189:112023. doi: 10.1016/j.ejmech.2019.112023. Epub 2020 Jan 2. Eur J Med Chem. 2020. PMID: 31978781 Free PMC article.
LINCS Data Portal 2.0: next generation access point for perturbation-response signatures.
Stathias V, Turner J, Koleti A, Vidovic D, Cooper D, Fazel-Najafabadi M, Pilarczyk M, Terryn R, Chung C, Umeano A, Clarke DJB, Lachmann A, Evangelista JE, Ma'ayan A, Medvedovic M, Schürer SC. Stathias V, et al. Nucleic Acids Res. 2020 Jan 8;48(D1):D431-D439. doi: 10.1093/nar/gkz1023. Nucleic Acids Res. 2020. PMID: 31701147 Free PMC article.
Drug and disease signature integration identifies synergistic combinations in glioblastoma.
Stathias V, Jermakowicz AM, Maloof ME, Forlin M, Walters W, Suter RK, Durante MA, Williams SL, Harbour JW, Volmar CH, Lyons NJ, Wahlestedt C, Graham RM, Ivan ME, Komotar RJ, Sarkaria JN, Subramanian A, Golub TR, Schürer SC, Ayad NG. Stathias V, et al. Nat Commun. 2018 Dec 14;9(1):5315. doi: 10.1038/s41467-018-07659-z. Nat Commun. 2018. PMID: 30552330 Free PMC article.
Connecting omics signatures and revealing biological mechanisms with iLINCS.
Pilarczyk M, Fazel-Najafabadi M, Kouril M, Shamsaei B, Vasiliauskas J, Niu W, Mahi N, Zhang L, Clark NA, Ren Y, White S, Karim R, Xu H, Biesiada J, Bennett MF, Davidson SE, Reichard JF, Roberts K, Stathias V, Koleti A, Vidovic D, Clarke DJB, Schürer SC, Ma'ayan A, Meller J, Medvedovic M. Pilarczyk M, et al. Among authors: schurer sc. Nat Commun. 2022 Aug 9;13(1):4678. doi: 10.1038/s41467-022-32205-3. Nat Commun. 2022. PMID: 35945222 Free PMC article.
The Genetic Landscape of Ocular Adnexa MALT Lymphoma Reveals Frequent Aberrations in NFAT and MEF2B Signaling Pathways.
Magistri M, Happ LE, Ramdial J, Lu X, Stathias V, Kunkalla K, Agarwal N, Jiang X, Schürer SC, Dubovy SR, Chapman JR, Vega F, Dave S, Lossos IS. Magistri M, et al. Among authors: schurer sc. Cancer Res Commun. 2021 Oct;1(1):1-16. doi: 10.1158/2767-9764.crc-21-0022. Epub 2021 Oct 13. Cancer Res Commun. 2021. PMID: 35528192 Free PMC article.
172 results