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Tyrosine phosphorylation of CARM1 promotes its enzymatic activity and alters its target specificity.
Nat Commun. 2024 Apr 22;15(1):3415. doi: 10.1038/s41467-024-47689-4.
Nat Commun. 2024.
PMID: 38649367
Free PMC article.
Dietary glucosamine overcomes the defects in αβ-T cell ontogeny caused by the loss of de novo hexosamine biosynthesis.
Werlen G, Li ML, Tottone L, da Silva-Diz V, Su X, Herranz D, Jacinto E.
Werlen G, et al. Among authors: tottone l.
Nat Commun. 2022 Dec 1;13(1):7404. doi: 10.1038/s41467-022-35014-w.
Nat Commun. 2022.
PMID: 36456551
Free PMC article.
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A Therapeutically Targetable NOTCH1-SIRT1-KAT7 Axis in T-cell Leukemia.
Lancho O, Singh A, da Silva-Diz V, Aleksandrova M, Khatun J, Tottone L, Nunes PR, Luo S, Zhao C, Zheng H, Chiles E, Zuo Z, Rocha PP, Su X, Khiabanian H, Herranz D.
Lancho O, et al. Among authors: tottone l.
Blood Cancer Discov. 2023 Jan 6;4(1):12-33. doi: 10.1158/2643-3230.BCD-22-0098.
Blood Cancer Discov. 2023.
PMID: 36322781
Free PMC article.
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A Tumor Suppressor Enhancer of PTEN in T-cell development and leukemia.
Tottone L, Lancho O, Loh JW, Singh A, Kimura S, Roels J, Kuchmiy A, Strubbe S, Lawlor MA, da Silva-Diz V, Luo S, Gachet S, García-Prieto CA, Hagelaar R, Esteller M, Meijerink JPP, Soulier J, Taghon T, Van Vlierberghe P, Mullighan CG, Khiabanian H, Rocha PP, Herranz D.
Tottone L, et al.
Blood Cancer Discov. 2021 Jan;2(1):92-109. doi: 10.1158/2643-3230.BCD-20-0201. Epub 2020 Nov 24.
Blood Cancer Discov. 2021.
PMID: 33458694
Free PMC article.
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Notch3 contributes to T-cell leukemia growth via regulation of the unfolded protein response.
Giuli MV, Diluvio G, Giuliani E, Franciosa G, Di Magno L, Pignataro MG, Tottone L, Nicoletti C, Besharat ZM, Peruzzi G, Pelullo M, Palermo R, Canettieri G, Talora C, d'Amati G, Bellavia D, Screpanti I, Checquolo S.
Giuli MV, et al. Among authors: tottone l.
Oncogenesis. 2020 Oct 18;9(10):93. doi: 10.1038/s41389-020-00279-7.
Oncogenesis. 2020.
PMID: 33071287
Free PMC article.
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Histone Modifications Drive Aberrant Notch3 Expression/Activity and Growth in T-ALL.
Tottone L, Zhdanovskaya N, Carmona Pestaña Á, Zampieri M, Simeoni F, Lazzari S, Ruocco V, Pelullo M, Caiafa P, Felli MP, Checquolo S, Bellavia D, Talora C, Screpanti I, Palermo R.
Tottone L, et al.
Front Oncol. 2019 Apr 3;9:198. doi: 10.3389/fonc.2019.00198. eCollection 2019.
Front Oncol. 2019.
PMID: 31001470
Free PMC article.
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Identification of a novel chalcone derivative that inhibits Notch signaling in T-cell acute lymphoblastic leukemia.
Mori M, Tottone L, Quaglio D, Zhdanovskaya N, Ingallina C, Fusto M, Ghirga F, Peruzzi G, Crestoni ME, Simeoni F, Giulimondi F, Talora C, Botta B, Screpanti I, Palermo R.
Mori M, et al. Among authors: tottone l.
Sci Rep. 2017 May 19;7(1):2213. doi: 10.1038/s41598-017-02316-9.
Sci Rep. 2017.
PMID: 28526832
Free PMC article.
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Notch and NF-kB signaling pathways regulate miR-223/FBXW7 axis in T-cell acute lymphoblastic leukemia.
Kumar V, Palermo R, Talora C, Campese AF, Checquolo S, Bellavia D, Tottone L, Testa G, Miele E, Indraccolo S, Amadori A, Ferretti E, Gulino A, Vacca A, Screpanti I.
Kumar V, et al. Among authors: tottone l.
Leukemia. 2014 Dec;28(12):2324-35. doi: 10.1038/leu.2014.133. Epub 2014 Apr 14.
Leukemia. 2014.
PMID: 24727676
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