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A global to local genomics analysis of Clostridioides difficile ST1/RT027 identifies cryptic transmission events in a northern Arizona healthcare network.
Williamson CHD, Stone NE, Nunnally AE, Hornstra HM, Wagner DM, Roe CC, Vazquez AJ, Nandurkar N, Vinocur J, Terriquez J, Gillece J, Travis J, Lemmer D, Keim P, Sahl JW. Williamson CHD, et al. Among authors: hornstra hm. Microb Genom. 2019 Jul;5(7):e000271. doi: 10.1099/mgen.0.000271. Epub 2019 May 20. Microb Genom. 2019. PMID: 31107202 Free PMC article.
A local-scale One Health genomic surveillance of Clostridioides difficile demonstrates highly related strains from humans, canines, and the environment.
Williamson CHD, Roe CC, Terriquez J, Hornstra H, Lucero S, Nunnally AE, Vazquez AJ, Vinocur J, Plude C, Nienstadt L, Stone NE, Celona KR, Wagner DM, Keim P, Sahl JW. Williamson CHD, et al. Microb Genom. 2023 Jun;9(6):mgen001046. doi: 10.1099/mgen.0.001046. Microb Genom. 2023. PMID: 37347682 Free PMC article.
Domestic canines do not display evidence of gut microbial dysbiosis in the presence of Clostridioides (Clostridium) difficile, despite cellular susceptibility to its toxins.
Stone NE, Nunnally AE, Jimenez V Jr, Cope EK, Sahl JW, Sheridan K, Hornstra HM, Vinocur J, Settles EW, Headley KC, Williamson CHD, Rideout JR, Bolyen E, Caporaso JG, Terriquez J, Monroy FP, Busch JD, Keim P, Wagner DM. Stone NE, et al. Among authors: hornstra hm. Anaerobe. 2019 Aug;58:53-72. doi: 10.1016/j.anaerobe.2019.03.017. Epub 2019 Apr 1. Anaerobe. 2019. PMID: 30946985 Free article.
Pathogen to commensal? Longitudinal within-host population dynamics, evolution, and adaptation during a chronic >16-year Burkholderia pseudomallei infection.
Pearson T, Sahl JW, Hepp CM, Handady K, Hornstra H, Vazquez AJ, Settles E, Mayo M, Kaestli M, Williamson CHD, Price EP, Sarovich DS, Cook JM, Wolken SR, Bowen RA, Tuanyok A, Foster JT, Drees KP, Kidd TJ, Bell SC, Currie BJ, Keim P. Pearson T, et al. PLoS Pathog. 2020 Mar 5;16(3):e1008298. doi: 10.1371/journal.ppat.1008298. eCollection 2020 Mar. PLoS Pathog. 2020. PMID: 32134991 Free PMC article.
Unprecedented Melioidosis Cases in Northern Australia Caused by an Asian Burkholderia pseudomallei Strain Identified by Using Large-Scale Comparative Genomics.
Price EP, Sarovich DS, Smith EJ, MacHunter B, Harrington G, Theobald V, Hall CM, Hornstra HM, McRobb E, Podin Y, Mayo M, Sahl JW, Wagner DM, Keim P, Kaestli M, Currie BJ. Price EP, et al. Among authors: hornstra hm. Appl Environ Microbiol. 2015 Nov 25;82(3):954-63. doi: 10.1128/AEM.03013-15. Print 2016 Feb 1. Appl Environ Microbiol. 2015. PMID: 26607593 Free PMC article.
When outgroups fail; phylogenomics of rooting the emerging pathogen, Coxiella burnetii.
Pearson T, Hornstra HM, Sahl JW, Schaack S, Schupp JM, Beckstrom-Sternberg SM, O'Neill MW, Priestley RA, Champion MD, Beckstrom-Sternberg JS, Kersh GJ, Samuel JE, Massung RF, Keim P. Pearson T, et al. Among authors: hornstra hm. Syst Biol. 2013 Sep;62(5):752-62. doi: 10.1093/sysbio/syt038. Epub 2013 Jun 4. Syst Biol. 2013. PMID: 23736103 Free PMC article.
41 results