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Condensate-promoting ENL mutation drives tumorigenesis in vivo through dynamic regulation of histone modifications and gene expression.
Cancer Discov. 2024 Apr 24. doi: 10.1158/2159-8290.CD-23-0876. Online ahead of print.
Cancer Discov. 2024.
PMID: 38655899
Having it both ways: how STAT3 deficiency blocks graft-versus-host disease while preserving graft-versus-leukemia activity.
Brandstadter JD, Outen R, Maillard I.
Brandstadter JD, et al. Among authors: outen r.
J Clin Invest. 2023 Aug 1;133(15):e172251. doi: 10.1172/JCI172251.
J Clin Invest. 2023.
PMID: 37526083
Free PMC article.
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Notch signaling drives intestinal graft-versus-host disease in mice and nonhuman primates.
Tkachev V, Vanderbeck A, Perkey E, Furlan SN, McGuckin C, Gómez Atria D, Gerdemann U, Rui X, Lane J, Hunt DJ, Zheng H, Colonna L, Hoffman M, Yu A, Outen R, Kelly S, Allman A, Koch U, Radtke F, Ludewig B, Burbach B, Shimizu Y, Panoskaltsis-Mortari A, Chen G, Carpenter SM, Harari O, Kuhnert F, Thurston G, Blazar BR, Kean LS, Maillard I.
Tkachev V, et al. Among authors: outen r.
Sci Transl Med. 2023 Jun 28;15(702):eadd1175. doi: 10.1126/scitranslmed.add1175. Epub 2023 Jun 28.
Sci Transl Med. 2023.
PMID: 37379368
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