Ascher DB - Search Results

1

Joint genotypic and phenotypic outcome modeling improves base editing variant effect quantification.

Ryu J, Barkal S, Yu T, Jankowiak M, Zhou Y, Francoeur M, Phan QV, Li Z, Tognon M, Brown L, Love MI, Bhat V, Lettre G, Ascher DB, Cassa CA, Sherwood RI, Pinello L. Ryu J, et al. Among authors: ascher db. Nat Genet. 2024 May;56(5):925-937. doi: 10.1038/s41588-024-01726-6. Epub 2024 Apr 24. Nat Genet. 2024. PMID: 38658794

2

Structure-guided machine learning prediction of drug resistance mutations in Abelson 1 kinase.

Zhou Y, Portelli S, Pat M, Rodrigues CHM, Nguyen TB, Pires DEV, Ascher DB. Zhou Y, et al. Among authors: ascher db. Comput Struct Biotechnol J. 2021 Sep 16;19:5381-5391. doi: 10.1016/j.csbj.2021.09.016. eCollection 2021. Comput Struct Biotechnol J. 2021. PMID: 34667533 Free PMC article.

3

kinCSM: Using graph-based signatures to predict small molecule CDK2 inhibitors.

Zhou Y, Al-Jarf R, Alavi A, Nguyen TB, Rodrigues CHM, Pires DEV, Ascher DB. Zhou Y, et al. Among authors: ascher db. Protein Sci. 2022 Nov;31(11):e4453. doi: 10.1002/pro.4453. Protein Sci. 2022. PMID: 36305769 Free PMC article.

4

DDMut: predicting effects of mutations on protein stability using deep learning.

Zhou Y, Pan Q, Pires DEV, Rodrigues CHM, Ascher DB. Zhou Y, et al. Among authors: ascher db. Nucleic Acids Res. 2023 Jul 5;51(W1):W122-W128. doi: 10.1093/nar/gkad472. Nucleic Acids Res. 2023. PMID: 37283042 Free PMC article.

5

Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for the EsxW Beijing variant in Vietnam.

Holt KE, McAdam P, Thai PVK, Thuong NTT, Ha DTM, Lan NN, Lan NH, Nhu NTQ, Hai HT, Ha VTN, Thwaites G, Edwards DJ, Nath AP, Pham K, Ascher DB, Farrar J, Khor CC, Teo YY, Inouye M, Caws M, Dunstan SJ. Holt KE, et al. Among authors: ascher db. Nat Genet. 2018 Jun;50(6):849-856. doi: 10.1038/s41588-018-0117-9. Epub 2018 May 21. Nat Genet. 2018. PMID: 29785015 Free PMC article.

6

Exploring the structural distribution of genetic variation in SARS-CoV-2 with the COVID-3D online resource.

Portelli S, Olshansky M, Rodrigues CHM, D'Souza EN, Myung Y, Silk M, Alavi A, Pires DEV, Ascher DB. Portelli S, et al. Among authors: ascher db. Nat Genet. 2020 Oct;52(10):999-1001. doi: 10.1038/s41588-020-0693-3. Nat Genet. 2020. PMID: 32908256 No abstract available.

7

Author Correction: Exploring the structural distribution of genetic variation in SARS-CoV-2 with the COVID-3D online resource.

Portelli S, Olshansky M, Rodrigues CHM, D'Souza EN, Myung Y, Silk M, Alavi A, Pires DEV, Ascher DB. Portelli S, et al. Among authors: ascher db. Nat Genet. 2021 Feb;53(2):254. doi: 10.1038/s41588-020-00775-x. Nat Genet. 2021. PMID: 33398199 Free PMC article. No abstract available.

8

Characterizing and predicting ccRCC-causing missense mutations in Von Hippel-Lindau disease.

Serghini A, Portelli S, Troadec G, Song C, Pan Q, Pires DEV, Ascher DB. Serghini A, et al. Among authors: ascher db. Hum Mol Genet. 2024 Jan 20;33(3):224-232. doi: 10.1093/hmg/ddad181. Hum Mol Genet. 2024. PMID: 37883464 Free PMC article.

9

Exploring the effects of missense mutations on protein thermodynamics through structure-based approaches: findings from the CAGI6 challenges.

Rodrigues CHM, Portelli S, Ascher DB. Rodrigues CHM, et al. Among authors: ascher db. Hum Genet. 2024 Jan 16. doi: 10.1007/s00439-023-02623-4. Online ahead of print. Hum Genet. 2024. PMID: 38227011

10

Identifying the molecular drivers of ALS-implicated missense mutations.

Portelli S, Albanaz A, Pires DEV, Ascher DB. Portelli S, et al. Among authors: ascher db. J Med Genet. 2023 May;60(5):484-490. doi: 10.1136/jmg-2022-108798. Epub 2022 Sep 30. J Med Genet. 2023. PMID: 36180205

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