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Human genetic diversity alters off-target outcomes of therapeutic gene editing.
Cancellieri S, Zeng J, Lin LY, Tognon M, Nguyen MA, Lin J, Bombieri N, Maitland SA, Ciuculescu MF, Katta V, Tsai SQ, Armant M, Wolfe SA, Giugno R, Bauer DE, Pinello L. Cancellieri S, et al. Among authors: pinello l. Nat Genet. 2023 Jan;55(1):34-43. doi: 10.1038/s41588-022-01257-y. Epub 2022 Dec 15. Nat Genet. 2023. PMID: 36522432 Free PMC article.
SIMBA: single-cell embedding along with features.
Chen H, Ryu J, Vinyard ME, Lerer A, Pinello L. Chen H, et al. Among authors: pinello l. Nat Methods. 2023 May 29. doi: 10.1038/s41592-023-01899-8. Online ahead of print. Nat Methods. 2023. PMID: 37248389
Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci.
Canver MC, Lessard S, Pinello L, Wu Y, Ilboudo Y, Stern EN, Needleman AJ, Galactéros F, Brugnara C, Kutlar A, McKenzie C, Reid M, Chen DD, Das PP, A Cole M, Zeng J, Kurita R, Nakamura Y, Yuan GC, Lettre G, Bauer DE, Orkin SH. Canver MC, et al. Among authors: pinello l. Nat Genet. 2017 Apr;49(4):625-634. doi: 10.1038/ng.3793. Epub 2017 Feb 20. Nat Genet. 2017. PMID: 28218758 Free PMC article.
A molecular glue approach to control the half-life of CRISPR-based technologies.
Sreekanth V, Jan M, Zhao KT, Lim D, Davis JR, McConkey M, Kovalcik V, Barkal S, Law BK, Fife J, Tian R, Vinyard ME, Becerra B, Kampmann M, Sherwood RI, Pinello L, Liu DR, Ebert BL, Choudhary A. Sreekanth V, et al. Among authors: pinello l. bioRxiv [Preprint]. 2023 Mar 20:2023.03.12.531757. doi: 10.1101/2023.03.12.531757. bioRxiv. 2023. PMID: 36945568 Free PMC article. Preprint.
GRAFIMO: Variant and haplotype aware motif scanning on pangenome graphs.
Tognon M, Bonnici V, Garrison E, Giugno R, Pinello L. Tognon M, et al. Among authors: pinello l. PLoS Comput Biol. 2021 Sep 27;17(9):e1009444. doi: 10.1371/journal.pcbi.1009444. eCollection 2021 Sep. PLoS Comput Biol. 2021. PMID: 34570769 Free PMC article.
120 results