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Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells.
Offensperger F, Tin G, Duran-Frigola M, Hahn E, Dobner S, Ende CWA, Strohbach JW, Rukavina A, Brennsteiner V, Ogilvie K, Marella N, Kladnik K, Ciuffa R, Majmudar JD, Field SD, Bensimon A, Ferrari L, Ferrada E, Ng A, Zhang Z, Degliesposti G, Boeszoermenyi A, Martens S, Stanton R, Müller AC, Hannich JT, Hepworth D, Superti-Furga G, Kubicek S, Schenone M, Winter GE. Offensperger F, et al. Among authors: boeszoermenyi a. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26. Science. 2024. PMID: 38662832
"Multiplexed screen identifies a Pseudomonas aeruginosa -specific small molecule targeting the outer membrane protein OprH and its interaction with LPS".
Poulsen BE, Warrier T, Barkho S, Bagnall J, Romano KP, White T, Yu X, Kawate T, Nguyen PH, Raines K, Ferrara K, Golas A, Fitzgerald M, Boeszoermenyi A, Kaushik V, Serrano-Wu M, Shoresh N, Hung DT. Poulsen BE, et al. Among authors: boeszoermenyi a. bioRxiv [Preprint]. 2024 Mar 16:2024.03.16.585348. doi: 10.1101/2024.03.16.585348. bioRxiv. 2024. PMID: 38559044 Free PMC article. Preprint.
Paralog-dependent isogenic cell assay cascade generates highly selective SLC16A3 inhibitors.
Dvorak V, Casiraghi A, Colas C, Koren A, Tomek T, Offensperger F, Rukavina A, Tin G, Hahn E, Dobner S, Frommelt F, Boeszoermenyi A, Bernada V, Hannich JT, Ecker GF, Winter GE, Kubicek S, Superti-Furga G. Dvorak V, et al. Among authors: boeszoermenyi a. Cell Chem Biol. 2023 Aug 17;30(8):953-964.e9. doi: 10.1016/j.chembiol.2023.06.029. Epub 2023 Jul 28. Cell Chem Biol. 2023. PMID: 37516113 Free PMC article.
The fission yeast FLCN/FNIP complex augments TORC1 repression or activation in response to amino acid (AA) availability.
Calvo IA, Sharma S, Paulo JA, Gulka AOD, Boeszoermenyi A, Zhang J, Lombana JM, Palmieri CM, Laviolette LA, Arthanari H, Iliopoulos O, Gygi SP, Motamedi M. Calvo IA, et al. Among authors: boeszoermenyi a. iScience. 2021 Oct 23;24(11):103338. doi: 10.1016/j.isci.2021.103338. eCollection 2021 Nov 19. iScience. 2021. PMID: 34805795 Free PMC article.
An open-source drug discovery platform enables ultra-large virtual screens.
Gorgulla C, Boeszoermenyi A, Wang ZF, Fischer PD, Coote PW, Padmanabha Das KM, Malets YS, Radchenko DS, Moroz YS, Scott DA, Fackeldey K, Hoffmann M, Iavniuk I, Wagner G, Arthanari H. Gorgulla C, et al. Among authors: boeszoermenyi a. Nature. 2020 Apr;580(7805):663-668. doi: 10.1038/s41586-020-2117-z. Epub 2020 Mar 9. Nature. 2020. PMID: 32152607 Free PMC article.
The T Cell Antigen Receptor α Transmembrane Domain Coordinates Triggering through Regulation of Bilayer Immersion and CD3 Subunit Associations.
Brazin KN, Mallis RJ, Boeszoermenyi A, Feng Y, Yoshizawa A, Reche PA, Kaur P, Bi K, Hussey RE, Duke-Cohan JS, Song L, Wagner G, Arthanari H, Lang MJ, Reinherz EL. Brazin KN, et al. Among authors: boeszoermenyi a. Immunity. 2018 Nov 20;49(5):829-841.e6. doi: 10.1016/j.immuni.2018.09.007. Epub 2018 Oct 30. Immunity. 2018. PMID: 30389415 Free PMC article.
28 results