Kuhn N - Search Results

1

Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition.

Stoll AC, Kemp CJ, Patterson JR, Kubik M, Kuhn N, Benskey M, Duffy MF, Luk KC, Sortwell CE. Stoll AC, et al. Among authors: kuhn n. J Neuroinflammation. 2024 Apr 25;21(1):108. doi: 10.1186/s12974-024-03108-5. J Neuroinflammation. 2024. PMID: 38664840 Free PMC article.

2

Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of α-synuclein-preformed fibril-induced toxicity and motor deficits.

Gezer AO, Kochmanski J, VanOeveren SE, Cole-Strauss A, Kemp CJ, Patterson JR, Miller KM, Kuhn NC, Herman DE, McIntire A, Lipton JW, Luk KC, Fleming SM, Sortwell CE, Bernstein AI. Gezer AO, et al. Neurobiol Dis. 2020 Jul;141:104947. doi: 10.1016/j.nbd.2020.104947. Epub 2020 May 15. Neurobiol Dis. 2020. PMID: 32422283 Free PMC article.

3

Dopaminergic Positron Emission Tomography Imaging in the Alpha-Synuclein Preformed Fibril Model Reveals Similarities to Early Parkinson's Disease.

Sossi V, Patterson JR, McCormick S, Kemp CJ, Miller KM, Stoll AC, Kuhn N, Kubik M, Kochmanski J, Luk KC, Sortwell CE. Sossi V, et al. Among authors: kuhn n. Mov Disord. 2022 Aug;37(8):1739-1748. doi: 10.1002/mds.29051. Epub 2022 May 7. Mov Disord. 2022. PMID: 35524682 Free PMC article.

4

Developmental exposure to the Parkinson's disease-associated organochlorine pesticide dieldrin alters dopamine neurotransmission in α-synuclein pre-formed fibril (PFF)-injected mice.

Boyd SL, Kuhn NC, Patterson JR, Stoll AC, Zimmerman SA, Kolanowski MR, Neubecker JJ, Luk KC, Ramsson ES, Sortwell CE, Bernstein AI. Boyd SL, et al. Toxicol Sci. 2023 Oct 30;196(1):99-111. doi: 10.1093/toxsci/kfad086. Toxicol Sci. 2023. PMID: 37607008 Free PMC article.

5

Deficits in basal and evoked striatal dopamine release following alpha-synuclein preformed fibril injection: An in vivo microdialysis study.

Centner A, Del Priore I, Chambers N, Cohen SR, Terry ML, Coyle M, Glinski J, Stoll AC, Patterson JR, Kemp CJ, Miller KM, Kubik M, Kuhn N, Luk KC, Sortwell CE, Bishop C. Centner A, et al. Among authors: kuhn n. Eur J Neurosci. 2024 Apr;59(7):1585-1603. doi: 10.1111/ejn.16275. Epub 2024 Feb 14. Eur J Neurosci. 2024. PMID: 38356120

6

Morphological and behavioral impact of AAV2/5-mediated overexpression of human wildtype alpha-synuclein in the rat nigrostriatal system.

Gombash SE, Manfredsson FP, Kemp CJ, Kuhn NC, Fleming SM, Egan AE, Grant LM, Ciucci MR, MacKeigan JP, Sortwell CE. Gombash SE, et al. PLoS One. 2013 Nov 27;8(11):e81426. doi: 10.1371/journal.pone.0081426. eCollection 2013. PLoS One. 2013. PMID: 24312298 Free PMC article.

7

Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology.

Manfredsson FP, Luk KC, Benskey MJ, Gezer A, Garcia J, Kuhn NC, Sandoval IM, Patterson JR, O'Mara A, Yonkers R, Kordower JH. Manfredsson FP, et al. Neurobiol Dis. 2018 Apr;112:106-118. doi: 10.1016/j.nbd.2018.01.008. Epub 2018 Jan 16. Neurobiol Dis. 2018. PMID: 29341898 Free PMC article.

8

Microglial depletion does not impact alpha-synuclein aggregation or nigrostriatal degeneration in the rat preformed fibril model.

Stoll AC, Kemp CJ, Patterson JR, Kubik M, Kuhn N, Benskey M, Duffy MF, Luk K, Sortwell CE. Stoll AC, et al. Among authors: kuhn n. Res Sq [Preprint]. 2023 May 4:rs.3.rs-2890683. doi: 10.21203/rs.3.rs-2890683/v1. Res Sq. 2023. PMID: 37205534 Free PMC article. Preprint.

9

Transcriptomic profiling of early synucleinopathy in rats induced with preformed fibrils.

Patterson JR, Kochmanski J, Stoll AC, Kubik M, Kemp CJ, Duffy MF, Thompson K, Howe JW, Cole-Strauss A, Kuhn NC, Miller KM, Nelson S, Onyekpe CU, Beck JS, Counts SE, Bernstein AI, Steece-Collier K, Luk KC, Sortwell CE. Patterson JR, et al. Among authors: kuhn nc. NPJ Parkinsons Dis. 2024 Jan 3;10(1):7. doi: 10.1038/s41531-023-00620-y. NPJ Parkinsons Dis. 2024. PMID: 38172128 Free PMC article.

10

Recombinant adenoassociated virus 2/5-mediated gene transfer is reduced in the aged rat midbrain.

Polinski NK, Gombash SE, Manfredsson FP, Lipton JW, Kemp CJ, Cole-Strauss A, Kanaan NM, Steece-Collier K, Kuhn NC, Wohlgenant SL, Sortwell CE. Polinski NK, et al. Neurobiol Aging. 2015 Feb;36(2):1110-20. doi: 10.1016/j.neurobiolaging.2014.07.047. Epub 2014 Oct 13. Neurobiol Aging. 2015. PMID: 25457558 Free PMC article.

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