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AiZynth impact on medicinal chemistry practice at AstraZeneca.
Shields JD, Howells R, Lamont G, Leilei Y, Madin A, Reimann CE, Rezaei H, Reuillon T, Smith B, Thomson C, Zheng Y, Ziegler RE. Shields JD, et al. Among authors: ziegler re. RSC Med Chem. 2024 Feb 16;15(4):1085-1095. doi: 10.1039/d3md00651d. eCollection 2024 Apr 24. RSC Med Chem. 2024. PMID: 38665822
Multiomic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation.
Erickson EC, You I, Perry G, Dugourd A, Donovan KA, Crafter C, Johannes JW, Williamson S, Moss JI, Ros S, Ziegler RE, Barry ST, Fischer ES, Gray NS, Madsen RR, Toker A. Erickson EC, et al. Among authors: ziegler re. Sci Signal. 2024 Feb 27;17(825):eadf2670. doi: 10.1126/scisignal.adf2670. Epub 2024 Feb 27. Sci Signal. 2024. PMID: 38412255 Free PMC article.
7-Step Flow Synthesis of the HIV Integrase Inhibitor Dolutegravir.
Ziegler RE, Desai BK, Jee JA, Gupton BF, Roper TD, Jamison TF. Ziegler RE, et al. Angew Chem Int Ed Engl. 2018 Jun 11;57(24):7181-7185. doi: 10.1002/anie.201802256. Epub 2018 May 14. Angew Chem Int Ed Engl. 2018. PMID: 29756689 Free PMC article.