Locher KP - Search Results

1

Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-κB.

Lampson BL, Ramίrez AS, Baro M, He L, Hegde M, Koduri V, Pfaff JL, Hanna RE, Kowal J, Shirole NH, He Y, Doench JG, Contessa JN, Locher KP, Kaelin WG Jr. Lampson BL, et al. Among authors: locher kp. Cell. 2024 Apr 25;187(9):2209-2223.e16. doi: 10.1016/j.cell.2024.03.022. Cell. 2024. PMID: 38670073 Free article.

2

Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B.

Ramírez AS, Kowal J, Locher KP. Ramírez AS, et al. Among authors: locher kp. Science. 2019 Dec 13;366(6471):1372-1375. doi: 10.1126/science.aaz3505. Science. 2019. PMID: 31831667

3

Structure of the yeast oligosaccharyltransferase complex gives insight into eukaryotic N-glycosylation.

Wild R, Kowal J, Eyring J, Ngwa EM, Aebi M, Locher KP. Wild R, et al. Among authors: locher kp. Science. 2018 Feb 2;359(6375):545-550. doi: 10.1126/science.aar5140. Epub 2018 Jan 4. Science. 2018. PMID: 29301962

4

Molecular basis for glycan recognition and reaction priming of eukaryotic oligosaccharyltransferase.

Ramírez AS, de Capitani M, Pesciullesi G, Kowal J, Bloch JS, Irobalieva RN, Reymond JL, Aebi M, Locher KP. Ramírez AS, et al. Among authors: locher kp. Nat Commun. 2022 Nov 26;13(1):7296. doi: 10.1038/s41467-022-35067-x. Nat Commun. 2022. PMID: 36435935 Free PMC article.

5

Structure of the Human Cholesterol Transporter ABCG1.

Skarda L, Kowal J, Locher KP. Skarda L, et al. Among authors: locher kp. J Mol Biol. 2021 Oct 15;433(21):167218. doi: 10.1016/j.jmb.2021.167218. Epub 2021 Aug 28. J Mol Biol. 2021. PMID: 34461069 Free article.

6

Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states.

Manolaridis I, Jackson SM, Taylor NMI, Kowal J, Stahlberg H, Locher KP. Manolaridis I, et al. Among authors: locher kp. Nature. 2018 Nov;563(7731):426-430. doi: 10.1038/s41586-018-0680-3. Epub 2018 Nov 7. Nature. 2018. PMID: 30405239 Free PMC article.

7

Structural insight into substrate and inhibitor discrimination by human P-glycoprotein.

Alam A, Kowal J, Broude E, Roninson I, Locher KP. Alam A, et al. Among authors: locher kp. Science. 2019 Feb 15;363(6428):753-756. doi: 10.1126/science.aav7102. Science. 2019. PMID: 30765569 Free PMC article.

8

Structure of the human lipid exporter ABCB4 in a lipid environment.

Olsen JA, Alam A, Kowal J, Stieger B, Locher KP. Olsen JA, et al. Among authors: locher kp. Nat Struct Mol Biol. 2020 Jan;27(1):62-70. doi: 10.1038/s41594-019-0354-3. Epub 2019 Dec 23. Nat Struct Mol Biol. 2020. PMID: 31873305 Free article.

9

Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1.

Nosol K, Romane K, Irobalieva RN, Alam A, Kowal J, Fujita N, Locher KP. Nosol K, et al. Among authors: locher kp. Proc Natl Acad Sci U S A. 2020 Oct 20;117(42):26245-26253. doi: 10.1073/pnas.2010264117. Epub 2020 Oct 5. Proc Natl Acad Sci U S A. 2020. PMID: 33020312 Free PMC article.

10

Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism.

Yu Q, Ni D, Kowal J, Manolaridis I, Jackson SM, Stahlberg H, Locher KP. Yu Q, et al. Among authors: locher kp. Nat Commun. 2021 Jul 19;12(1):4376. doi: 10.1038/s41467-021-24651-2. Nat Commun. 2021. PMID: 34282134 Free PMC article.

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