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In Vitro Characterization of 6-Methyl-3-(2-nitro-1-(thiophen-2-yl)ethyl)-2-phenyl-1H-indole (ZCZ011) at the Type 1 Cannabinoid Receptor: Allosteric Agonist or Allosteric Modulator?
Green HM, Finlay DB, Ross RA, Greig IR, Duffull SB, Glass M. Green HM, et al. Among authors: greig ir. ACS Pharmacol Transl Sci. 2022 Nov 22;5(12):1279-1291. doi: 10.1021/acsptsci.2c00160. eCollection 2022 Dec 9. ACS Pharmacol Transl Sci. 2022. PMID: 36524007 Free PMC article.
The atypical 'hippocampal' glutamate receptor coupled to phospholipase D that controls stretch-sensitivity in primary mechanosensory nerve endings is homomeric purely metabotropic GluK2.
Thompson KJ, Watson S, Zanato C, Dall'Angelo S, De Nooij JC, Pace-Bonello B, Shenton FC, Sanger HE, Heinz BA, Broad LM, Grosjean N, McQuillian JR, Dubini M, Pyner S, Greig I, Zanda M, Bleakman D, Banks RW, Bewick GS. Thompson KJ, et al. Among authors: greig i. Exp Physiol. 2024 Jan;109(1):81-99. doi: 10.1113/EP090761. Epub 2023 Sep 1. Exp Physiol. 2024. PMID: 37656490 Free PMC article. Review.
A novel allosteric modulator of the cannabinoid CB1 receptor ameliorates hyperdopaminergia endophenotypes in rodent models.
Mielnik CA, Sugamori KS, Finlay DB, Thorpe HHA, Schapira M, Sivananthan N, Li CK, Lam VM, Harrington S, Abdelrahman MH, Trembleau LA, McIntyre Burnham W, Khokhar JY, Salahpour A, Ramsey AJ, Glass M, Greig IR, Ross RA. Mielnik CA, et al. Among authors: greig ir. Neuropsychopharmacology. 2021 Jan;46(2):413-422. doi: 10.1038/s41386-020-00876-5. Epub 2020 Oct 8. Neuropsychopharmacology. 2021. PMID: 33036015 Free PMC article.
55 results