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Discovery of a novel series of medium-sized cyclic enteropeptidase inhibitors.
Kikuchi F, Ikeda Z, Kakegawa K, Nishikawa Y, Sasaki S, Fukuda K, Takami K, Banno Y, Nishikawa H, Taya N, Nakahata T, Itono S, Yashiro H, Tsuchimori K, Hiyoshi H, Sasaki M, Tohyama K, Matsumiya K, Ishihara Y, Kawamoto T, Kamaura M, Watanabe M, Kitazaki T, Maekawa T, Sasaki M. Kikuchi F, et al. Among authors: kakegawa k. Bioorg Med Chem. 2023 Oct 1;93:117462. doi: 10.1016/j.bmc.2023.117462. Epub 2023 Aug 29. Bioorg Med Chem. 2023. PMID: 37683572 Free article.
Design, Synthesis, and Biological Evaluation of a Novel Series of 4-Guanidinobenzoate Derivatives as Enteropeptidase Inhibitors with Low Systemic Exposure for the Treatment of Obesity.
Ikeda Z, Kakegawa K, Kikuchi F, Itono S, Oki H, Yashiro H, Hiyoshi H, Tsuchimori K, Hamagami K, Watanabe M, Sasaki M, Ishihara Y, Tohyama K, Kitazaki T, Maekawa T, Sasaki M. Ikeda Z, et al. Among authors: kakegawa k. J Med Chem. 2022 Jun 23;65(12):8456-8477. doi: 10.1021/acs.jmedchem.2c00463. Epub 2022 Jun 10. J Med Chem. 2022. PMID: 35686954 Free PMC article.
Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore.
Tanaka Y, Seto M, Kakegawa K, Takami K, Kikuchi F, Yamamoto T, Nakamura M, Daini M, Murakami M, Ohashi T, Kasahara T, Wang J, Ikeda Z, Wada Y, Puenner F, Fujii T, Inazuka M, Sato S, Suzaki T, Oak JH, Takai Y, Kohara H, Kimoto K, Oki H, Mikami S, Sasaki M, Tanaka Y. Tanaka Y, et al. Among authors: kakegawa k. J Med Chem. 2022 Mar 10;65(5):4270-4290. doi: 10.1021/acs.jmedchem.1c02078. Epub 2022 Feb 21. J Med Chem. 2022. PMID: 35188773 Free article.
Association between endotoxemia and histological features of nonalcoholic fatty liver disease.
Kitabatake H, Tanaka N, Fujimori N, Komatsu M, Okubo A, Kakegawa K, Kimura T, Sugiura A, Yamazaki T, Shibata S, Ichikawa Y, Joshita S, Umemura T, Matsumoto A, Koinuma M, Sano K, Aoyama T, Tanaka E. Kitabatake H, et al. Among authors: kakegawa k. World J Gastroenterol. 2017 Jan 28;23(4):712-722. doi: 10.3748/wjg.v23.i4.712. World J Gastroenterol. 2017. PMID: 28216979 Free PMC article.
Amine-free melanin-concentrating hormone receptor 1 antagonists: Novel non-basic 1-(2H-indazole-5-yl)pyridin-2(1H)-one derivatives and mitigation of mutagenicity in Ames test.
Igawa H, Takahashi M, Ikoma M, Kaku H, Kakegawa K, Kina A, Aida J, Okuda S, Kawata Y, Noguchi T, Hotta N, Yamamoto S, Nakayama M, Nagisa Y, Kasai S, Maekawa T. Igawa H, et al. Among authors: kakegawa k. Bioorg Med Chem. 2016 Jun 1;24(11):2504-2518. doi: 10.1016/j.bmc.2016.04.013. Epub 2016 Apr 7. Bioorg Med Chem. 2016. PMID: 27117261
34 results