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Intra-islet glucagon signalling regulates beta-cell connectivity, first-phase insulin secretion and glucose homoeostasis.
Suba K, Patel Y, Martin-Alonso A, Hansen B, Xu X, Roberts A, Norton M, Chung P, Shrewsbury J, Kwok R, Kalogianni V, Cheng S, Liu X, Kalyviotis K, Rutter GA, Jones B, Minnion J, Owen BM, Pantazis P, Distaso W, Drucker DJ, Tan TM, Bloom SR, Murphy KG, Salem V. Suba K, et al. Among authors: drucker dj. Mol Metab. 2024 Apr 26:101947. doi: 10.1016/j.molmet.2024.101947. Online ahead of print. Mol Metab. 2024. PMID: 38677509 Free article.
Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice.
Akindehin S, Liskiewicz A, Liskiewicz D, Bernecker M, Garcia-Caceres C, Drucker DJ, Finan B, Grandl G, Gutgesell R, Hofmann SM, Khalil A, Liu X, Cota P, Bakhti M, Czarnecki O, Bastidas-Ponce A, Lickert H, Kang L, Maity G, Novikoff A, Parlee S, Pathak E, Schriever SC, Sterr M, Ussar S, Zhang Q, DiMarchi R, Tschöp MH, Pfluger PT, Douros JD, Müller TD. Akindehin S, et al. Among authors: drucker dj. Mol Metab. 2024 May;83:101915. doi: 10.1016/j.molmet.2024.101915. Epub 2024 Mar 14. Mol Metab. 2024. PMID: 38492844 Free PMC article.
Downregulation of the kidney glucagon receptor, essential for renal function and systemic homeostasis, contributes to chronic kidney disease.
Wang MY, Zhang Z, Zhao S, Onodera T, Sun XN, Zhu Q, Li C, Li N, Chen S, Paredes M, Gautron L, Charron MJ, Marciano DK, Gordillo R, Drucker DJ, Scherer PE. Wang MY, et al. Among authors: drucker dj. Cell Metab. 2024 Mar 5;36(3):575-597.e7. doi: 10.1016/j.cmet.2023.12.024. Epub 2024 Jan 17. Cell Metab. 2024. PMID: 38237602
Glucagon-like peptide-1 receptor signaling modifies the extent of diabetic kidney disease through dampening the receptor for advanced glycation end products-induced inflammation.
Sourris KC, Ding Y, Maxwell SS, Al-Sharea A, Kantharidis P, Mohan M, Rosado CJ, Penfold SA, Haase C, Xu Y, Forbes JM, Crawford S, Ramm G, Harcourt BE, Jandeleit-Dahm K, Advani A, Murphy AJ, Timmermann DB, Karihaloo A, Knudsen LB, El-Osta A, Drucker DJ, Cooper ME, Coughlan MT. Sourris KC, et al. Among authors: drucker dj. Kidney Int. 2024 Jan;105(1):132-149. doi: 10.1016/j.kint.2023.09.029. Epub 2023 Dec 8. Kidney Int. 2024. PMID: 38069998 Free article.
411 results