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Incomplete-penetrant hypertrophic cardiomyopathy MYH7 G256E mutation causes hypercontractility and elevated mitochondrial respiration.
Lee S, Vander Roest AS, Blair CA, Kao K, Bremner SB, Childers MC, Pathak D, Heinrich P, Lee D, Chirikian O, Mohran SE, Roberts B, Smith JE, Jahng JW, Paik DT, Wu JC, Gunawardane RN, Ruppel KM, Mack DL, Pruitt BL, Regnier M, Wu SM, Spudich JA, Bernstein D. Lee S, et al. Among authors: regnier m. Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2318413121. doi: 10.1073/pnas.2318413121. Epub 2024 Apr 29. Proc Natl Acad Sci U S A. 2024. PMID: 38683993
Cardiac myosin activation with 2-deoxy-ATP via increased electrostatic interactions with actin.
Powers JD, Yuan CC, McCabe KJ, Murray JD, Childers MC, Flint GV, Moussavi-Harami F, Mohran S, Castillo R, Zuzek C, Ma W, Daggett V, McCulloch AD, Irving TC, Regnier M. Powers JD, et al. Among authors: regnier m. Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11502-11507. doi: 10.1073/pnas.1905028116. Epub 2019 May 20. Proc Natl Acad Sci U S A. 2019. PMID: 31110001 Free PMC article.
Multi-scale models reveal hypertrophic cardiomyopathy MYH7 G256E mutation drives hypercontractility and elevated mitochondrial respiration.
Lee S, Roest ASV, Blair CA, Kao K, Bremner SB, Childers MC, Pathak D, Heinrich P, Lee D, Chirikian O, Mohran S, Roberts B, Smith JE, Jahng JW, Paik DT, Wu JC, Gunawardane RN, Spudich JA, Ruppel K, Mack D, Pruitt BL, Regnier M, Wu SM, Bernstein D. Lee S, et al. Among authors: regnier m. bioRxiv [Preprint]. 2023 Jun 9:2023.06.08.544276. doi: 10.1101/2023.06.08.544276. bioRxiv. 2023. PMID: 37333118 Free PMC article. Updated. Preprint.
Atomistic Simulations of Sarcomere Proteins.
Childers MC, Regnier M. Childers MC, et al. Among authors: regnier m. Methods Mol Biol. 2024;2735:27-41. doi: 10.1007/978-1-0716-3527-8_3. Methods Mol Biol. 2024. PMID: 38038842
A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy.
Davis J, Davis LC, Correll RN, Makarewich CA, Schwanekamp JA, Moussavi-Harami F, Wang D, York AJ, Wu H, Houser SR, Seidman CE, Seidman JG, Regnier M, Metzger JM, Wu JC, Molkentin JD. Davis J, et al. Among authors: regnier m. Cell. 2016 May 19;165(5):1147-1159. doi: 10.1016/j.cell.2016.04.002. Epub 2016 Apr 21. Cell. 2016. PMID: 27114035 Free PMC article.
Isolation and Mechanical Measurements of Myofibrils from Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Pioner JM, Racca AW, Klaiman JM, Yang KC, Guan X, Pabon L, Muskheli V, Zaunbrecher R, Macadangdang J, Jeong MY, Mack DL, Childers MK, Kim DH, Tesi C, Poggesi C, Murry CE, Regnier M. Pioner JM, et al. Among authors: regnier m. Stem Cell Reports. 2016 Jun 14;6(6):885-896. doi: 10.1016/j.stemcr.2016.04.006. Epub 2016 May 5. Stem Cell Reports. 2016. PMID: 27161364 Free PMC article.
Absence of full-length dystrophin impairs normal maturation and contraction of cardiomyocytes derived from human-induced pluripotent stem cells.
Pioner JM, Guan X, Klaiman JM, Racca AW, Pabon L, Muskheli V, Macadangdang J, Ferrantini C, Hoopmann MR, Moritz RL, Kim DH, Tesi C, Poggesi C, Murry CE, Childers MK, Mack DL, Regnier M. Pioner JM, et al. Among authors: regnier m. Cardiovasc Res. 2020 Feb 1;116(2):368-382. doi: 10.1093/cvr/cvz109. Cardiovasc Res. 2020. PMID: 31049579 Free PMC article.
Modulation of post-powerstroke dynamics in myosin II by 2'-deoxy-ADP.
Childers MC, Geeves M, Daggett V, Regnier M. Childers MC, et al. Among authors: regnier m. Arch Biochem Biophys. 2021 Mar 15;699:108733. doi: 10.1016/j.abb.2020.108733. Epub 2020 Dec 31. Arch Biochem Biophys. 2021. PMID: 33388313 Free PMC article.
356 results