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Incomplete-penetrant hypertrophic cardiomyopathy MYH7 G256E mutation causes hypercontractility and elevated mitochondrial respiration.
Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2318413121. doi: 10.1073/pnas.2318413121. Epub 2024 Apr 29.
Proc Natl Acad Sci U S A. 2024.
PMID: 38683993
Cryo-electron tomography reveals the structural diversity of cardiac proteins in their cellular context.
Woldeyes RA, Nishiga M, Vander Roest AS, Engel L, Giri P, Montenegro GC, Wu AC, Dunn AR, Spudich JA, Bernstein D, Schmid MF, Wu JC, Chiu W.
Woldeyes RA, et al. Among authors: vander roest as.
bioRxiv [Preprint]. 2023 Oct 26:2023.10.26.564098. doi: 10.1101/2023.10.26.564098.
bioRxiv. 2023.
PMID: 37961228
Free PMC article.
Preprint.
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Altered Cardiac Energetics and Mitochondrial Dysfunction in Hypertrophic Cardiomyopathy.
Ranjbarvaziri S, Kooiker KB, Ellenberger M, Fajardo G, Zhao M, Vander Roest AS, Woldeyes RA, Koyano TT, Fong R, Ma N, Tian L, Traber GM, Chan F, Perrino J, Reddy S, Chiu W, Wu JC, Woo JY, Ruppel KM, Spudich JA, Snyder MP, Contrepois K, Bernstein D.
Ranjbarvaziri S, et al. Among authors: vander roest as.
Circulation. 2021 Nov 23;144(21):1714-1731. doi: 10.1161/CIRCULATIONAHA.121.053575. Epub 2021 Oct 21.
Circulation. 2021.
PMID: 34672721
Free PMC article.
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Hypertrophic cardiomyopathy β-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super relaxed state.
Vander Roest AS, Liu C, Morck MM, Kooiker KB, Jung G, Song D, Dawood A, Jhingran A, Pardon G, Ranjbarvaziri S, Fajardo G, Zhao M, Campbell KS, Pruitt BL, Spudich JA, Ruppel KM, Bernstein D.
Vander Roest AS, et al.
Proc Natl Acad Sci U S A. 2021 Jun 15;118(24):e2025030118. doi: 10.1073/pnas.2025030118.
Proc Natl Acad Sci U S A. 2021.
PMID: 34117120
Free PMC article.
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