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A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B.
Aliagas-Martin I, Burdick D, Corson L, Dotson J, Drummond J, Fields C, Huang OW, Hunsaker T, Kleinheinz T, Krueger E, Liang J, Moffat J, Phillips G, Pulk R, Rawson TE, Ultsch M, Walker L, Wiesmann C, Zhang B, Zhu BY, Cochran AG. Aliagas-Martin I, et al. Among authors: rawson te. J Med Chem. 2009 May 28;52(10):3300-7. doi: 10.1021/jm9000314. J Med Chem. 2009. PMID: 19402633
A pentacyclic aurora kinase inhibitor (AKI-001) with high in vivo potency and oral bioavailability.
Rawson TE, Rüth M, Blackwood E, Burdick D, Corson L, Dotson J, Drummond J, Fields C, Georges GJ, Goller B, Halladay J, Hunsaker T, Kleinheinz T, Krell HW, Li J, Liang J, Limberg A, McNutt A, Moffat J, Phillips G, Ran Y, Safina B, Ultsch M, Walker L, Wiesmann C, Zhang B, Zhou A, Zhu BY, Rüger P, Cochran AG. Rawson TE, et al. J Med Chem. 2008 Aug 14;51(15):4465-75. doi: 10.1021/jm800052b. Epub 2008 Jul 17. J Med Chem. 2008. PMID: 18630890
Preparation and biological activity of novel tricyclic GPIIb/IIIa antagonists.
Robarge KD, Dina MS, Somers TC, Lee A, Rawson TE, Olivero AG, Tischler MH, Webb RR 2nd, Weese KJ, Aliagas I, Blackburn BK. Robarge KD, et al. Among authors: rawson te. Bioorg Med Chem. 1998 Dec;6(12):2345-81. doi: 10.1016/s0968-0896(98)80013-8. Bioorg Med Chem. 1998. PMID: 9925295
Growth hormone secretagogues: characterization, efficacy, and minimal bioactive conformation.
McDowell RS, Elias KA, Stanley MS, Burdick DJ, Burnier JP, Chan KS, Fairbrother WJ, Hammonds RG, Ingle GS, Jacobsen NE, Mortensen DL, Rawson TE, Won WB, Clark RG, Somers TC. McDowell RS, et al. Among authors: rawson te. Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):11165-9. doi: 10.1073/pnas.92.24.11165. Proc Natl Acad Sci U S A. 1995. PMID: 7479958 Free PMC article.
Benzodiazepine peptidomimetic inhibitors of farnesyltransferase.
Marsters JC Jr, McDowell RS, Reynolds ME, Oare DA, Somers TC, Stanley MS, Rawson TE, Struble ME, Burdick DJ, Chan KS, et al. Marsters JC Jr, et al. Among authors: rawson te. Bioorg Med Chem. 1994 Sep;2(9):949-57. doi: 10.1016/s0968-0896(00)82044-1. Bioorg Med Chem. 1994. PMID: 7712130
11 results