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A benign cultured colon adenoma bears three genetically altered colon cancer oncogenes, but progresses to tumorigenicity and transforming growth factor-beta independence without inactivating the p53 tumor suppressor gene.
Markowitz SD, Myeroff L, Cooper MJ, Traicoff J, Kochera M, Lutterbaugh J, Swiriduk M, Willson JK. Markowitz SD, et al. Among authors: myeroff l. J Clin Invest. 1994 Mar;93(3):1005-13. doi: 10.1172/JCI117048. J Clin Invest. 1994. PMID: 8132740 Free PMC article.
Mutational inactivation of TGFBR2 in microsatellite unstable colon cancer arises from the cooperation of genomic instability and the clonal outgrowth of transforming growth factor beta resistant cells.
Biswas S, Trobridge P, Romero-Gallo J, Billheimer D, Myeroff LL, Willson JK, Markowitz SD, Grady WM. Biswas S, et al. Among authors: myeroff ll. Genes Chromosomes Cancer. 2008 Feb;47(2):95-106. doi: 10.1002/gcc.20511. Genes Chromosomes Cancer. 2008. PMID: 17985359
Chromosomal autonomy of hMLH1 methylation in colon cancer.
Li H, Myeroff L, Kasturi L, Krumroy L, Schwartz S, Willson JK, Stanbridge E, Casey G, Markowitz S. Li H, et al. Among authors: myeroff l. Oncogene. 2002 Feb 21;21(9):1443-9. doi: 10.1038/sj.onc.1205247. Oncogene. 2002. PMID: 11857087
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