Njoroge FG - Search Results

1

Structural interaction of natural and synthetic inhibitors with the venom metalloproteinase, atrolysin C (form d).

Zhang D, Botos I, Gomis-Rüth FX, Doll R, Blood C, Njoroge FG, Fox JW, Bode W, Meyer EF. Zhang D, et al. Among authors: njoroge fg. Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8447-51. doi: 10.1073/pnas.91.18.8447. Proc Natl Acad Sci U S A. 1994. PMID: 8078901 Free PMC article.

2

Tricyclic farnesyl protein transferase inhibitors: crystallographic and calorimetric studies of structure-activity relationships.

Strickland CL, Weber PC, Windsor WT, Wu Z, Le HV, Albanese MM, Alvarez CS, Cesarz D, del Rosario J, Deskus J, Mallams AK, Njoroge FG, Piwinski JJ, Remiszewski S, Rossman RR, Taveras AG, Vibulbhan B, Doll RJ, Girijavallabhan VM, Ganguly AK. Strickland CL, et al. Among authors: njoroge fg. J Med Chem. 1999 Jun 17;42(12):2125-35. doi: 10.1021/jm990030g. J Med Chem. 1999. PMID: 10377218

3

Synthesis of C-11 methyl-substituted benzocycloheptapyridine inhibitors of farnesyl protein transferase.

Njoroge FG, Vibulbhan B, Wong JK, White SK, Wong SC, Carruthers NI, Kaminski JJ, Doll RJ, Girijavallabhan V, Ganguly AK. Njoroge FG, et al. Org Lett. 1999 Nov 4;1(9):1371-3. doi: 10.1021/ol990218u. Org Lett. 1999. PMID: 10825985

4

Towards the second generation of Boceprevir: Dithianes as an alternative P2 substituent for 2,2-dimethyl cycloproyl proline in HCV NS3 protease inhibitors.

Nair LG, Bogen S, Ruan S, Pan W, Pike R, Tong X, Cheng KC, Guo Z, Doll RJ, Njoroge FG. Nair LG, et al. Among authors: njoroge fg. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1689-92. doi: 10.1016/j.bmcl.2010.01.037. Epub 2010 Jan 20. Bioorg Med Chem Lett. 2010. PMID: 20149655

5

Potent, selective, and orally bioavailable tricyclic pyridyl acetamide N-oxide inhibitors of farnesyl protein transferase with enhanced in vivo antitumor activity.

Njoroge FG, Vibulbhan B, Pinto P, Bishop WR, Bryant MS, Nomeir AA, Lin C, Liu M, Doll RJ, Girijavallabhan V, Ganguly AK. Njoroge FG, et al. J Med Chem. 1998 May 7;41(10):1561-7. doi: 10.1021/jm980013b. J Med Chem. 1998. PMID: 9572881

6

Atropisomeric trihalobenzocycloheptapyridine analogues provide stereoselective FPT inhibitors with antitumor activity.

Njoroge FG, Vibulbhan B, Bishop WR, Kirschmeier P, Bryant MS, Nomeir AA, Liu M, Doll RJ, Girijavallabhan VM, Ganguly AK. Njoroge FG, et al. Bioorg Med Chem. 1999 May;7(5):861-7. doi: 10.1016/s0968-0896(99)00052-8. Bioorg Med Chem. 1999. PMID: 10400339

7

Discovery of novel nonpeptide tricyclic inhibitors of Ras farnesyl protein transferase.

Njoroge FG, Doll RJ, Vibulbhan B, Alvarez CS, Bishop WR, Petrin J, Kirschmeier P, Carruthers NI, Wong JK, Albanese MM, Piwinski JJ, Catino J, Girijavallabhan V, Ganguly AK. Njoroge FG, et al. Bioorg Med Chem. 1997 Jan;5(1):101-13. doi: 10.1016/s0968-0896(96)00206-4. Bioorg Med Chem. 1997. PMID: 9043662

8

Discovery of potent sulfonamide P4-capped ketoamide second generation inhibitors of hepatitis C virus NS3 serine protease with favorable pharmacokinetic profiles in preclinical species.

Bogen SL, Arasappan A, Velazquez F, Blackman M, Huelgas R, Pan W, Siegel E, Nair LG, Venkatraman S, Guo Z, Doll R, Shih NY, Njoroge FG. Bogen SL, et al. Among authors: njoroge fg. Bioorg Med Chem. 2010 Mar 1;18(5):1854-65. doi: 10.1016/j.bmc.2010.01.044. Epub 2010 Jan 25. Bioorg Med Chem. 2010. PMID: 20149666

9

Structure-activity relationship of 3-substituted N-(pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene )- piperidine inhibitors of farnesyl-protein transferase: design and synthesis of in vivo active antitumor compounds.

Njoroge FG, Vibulbhan B, Rane DF, Bishop WR, Petrin J, Patton R, Bryant MS, Chen KJ, Nomeir AA, Lin CC, Liu M, King I, Chen J, Lee S, Yaremko B, Dell J, Lipari P, Malkowski M, Li Z, Catino J, Doll RJ, Girijavallabhan V, Ganguly AK. Njoroge FG, et al. J Med Chem. 1997 Dec 19;40(26):4290-301. doi: 10.1021/jm970464g. J Med Chem. 1997. PMID: 9435898

10

A farnesyl transferase inhibitor suppresses TPA-mediated skin tumor development without altering hyperplasia in the ras transgenic Tg.AC mouse.

Trempus CS, Bishop WR, Njoroge FG, Doll RJ, Battalora MS, Mahler JF, Haseman JK, Tennant RW. Trempus CS, et al. Among authors: njoroge fg. Mol Carcinog. 2000 Jan;27(1):24-33. doi: 10.1002/(sici)1098-2744(200001)27:1<24::aid-mc5>3.0.co;2-m. Mol Carcinog. 2000. PMID: 10642434

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