Platelet-derived growth factor-induced activation of sphingosine kinase requires phosphorylation of the PDGF receptor tyrosine residue responsible for binding of PLCgamma.
Olivera A, Edsall L, Poulton S, Kazlauskas A, Spiegel S.
Olivera A, et al. Among authors: kazlauskas a.
FASEB J. 1999 Sep;13(12):1593-600. doi: 10.1096/fasebj.13.12.1593.
FASEB J. 1999.
PMID: 10463951
Sphingosine-1-phosphate, a sphingolipid metabolite, is involved in the mitogenic response of platelet-derived growth factor (PDGF) and is formed by activation of sphingosine kinase. ...Moreover, calcium mobilization downstream of PLCgamma, but not protein kinase C activati …
Sphingosine-1-phosphate, a sphingolipid metabolite, is involved in the mitogenic response of platelet-derived growth factor (PDGF) an …