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Infection with human immunodeficiency virus type 1 upregulates DNA methyltransferase, resulting in de novo methylation of the gamma interferon (IFN-gamma) promoter and subsequent downregulation of IFN-gamma production.
Mikovits JA, Young HA, Vertino P, Issa JP, Pitha PM, Turcoski-Corrales S, Taub DD, Petrow CL, Baylin SB, Ruscetti FW. Mikovits JA, et al. Among authors: pitha pm. Mol Cell Biol. 1998 Sep;18(9):5166-77. doi: 10.1128/MCB.18.9.5166. Mol Cell Biol. 1998. PMID: 9710601 Free PMC article.
Introduction: interferon's connection to cancer.
Pitha PM. Pitha PM. Semin Cancer Biol. 2000 Apr;10(2):69-72. doi: 10.1006/scbi.2000.0309. Semin Cancer Biol. 2000. PMID: 10936057 Free article. Review. No abstract available.
The proximal tyrosines of the cytoplasmic domain of the beta chain of the type I interferon receptor are essential for signal transducer and activator of transcription (Stat) 2 activation. Evidence that two Stat2 sites are required to reach a threshold of interferon alpha-induced Stat2 tyrosine phosphorylation that allows normal formation of interferon-stimulated gene factor 3.
Nadeau OW, Domanski P, Usacheva A, Uddin S, Platanias LC, Pitha P, Raz R, Levy D, Majchrzak B, Fish E, Colamonici OR. Nadeau OW, et al. Among authors: pitha p. J Biol Chem. 1999 Feb 12;274(7):4045-52. doi: 10.1074/jbc.274.7.4045. J Biol Chem. 1999. PMID: 9933596 Free article.
230 results