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Drug-resistant Drosophila indicate glutamate-gated chloride channels are targets for the antiparasitics nodulisporic acid and ivermectin.
Kane NS, Hirschberg B, Qian S, Hunt D, Thomas B, Brochu R, Ludmerer SW, Zheng Y, Smith M, Arena JP, Cohen CJ, Schmatz D, Warmke J, Cully DF. Kane NS, et al. Among authors: cohen cj. Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13949-54. doi: 10.1073/pnas.240464697. Proc Natl Acad Sci U S A. 2000. PMID: 11095718 Free PMC article.
Discovery of potent and use-dependent sodium channel blockers for treatment of chronic pain.
Liang J, Brochu RM, Cohen CJ, Dick IE, Felix JP, Fisher MH, Garcia ML, Kaczorowski GJ, Lyons KA, Meinke PT, Priest BT, Schmalhofer WA, Smith MM, Tarpley JW, Williams BS, Martin WJ, Parsons WH. Liang J, et al. Among authors: cohen cj. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2943-7. doi: 10.1016/j.bmcl.2005.02.093. Bioorg Med Chem Lett. 2005. PMID: 15878274
Two tarantula peptides inhibit activation of multiple sodium channels.
Middleton RE, Warren VA, Kraus RL, Hwang JC, Liu CJ, Dai G, Brochu RM, Kohler MG, Gao YD, Garsky VM, Bogusky MJ, Mehl JT, Cohen CJ, Smith MM. Middleton RE, et al. Among authors: cohen cj. Biochemistry. 2002 Dec 17;41(50):14734-47. doi: 10.1021/bi026546a. Biochemistry. 2002. PMID: 12475222
346 results