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A receptor in pituitary and hypothalamus that functions in growth hormone release.
Howard AD, Feighner SD, Cully DF, Arena JP, Liberator PA, Rosenblum CI, Hamelin M, Hreniuk DL, Palyha OC, Anderson J, Paress PS, Diaz C, Chou M, Liu KK, McKee KK, Pong SS, Chaung LY, Elbrecht A, Dashkevicz M, Heavens R, Rigby M, Sirinathsinghji DJ, Dean DC, Melillo DG, Patchett AA, Nargund R, Griffin PR, DeMartino JA, Gupta SK, Schaeffer JM, Smith RG, Van der Ploeg LH. Howard AD, et al. Among authors: patchett aa. Science. 1996 Aug 16;273(5277):974-7. doi: 10.1126/science.273.5277.974. Science. 1996. PMID: 8688086
Highly potent growth hormone secretagogues.
Lu Z, Tata JR, Cheng K, Wei L, Chan WW, Butler B, Schleim KD, Jacks TM, Hickey G, Patchett AA. Lu Z, et al. Among authors: patchett aa. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3657-9. doi: 10.1016/j.bmcl.2007.04.050. Epub 2007 Apr 25. Bioorg Med Chem Lett. 2007. PMID: 17482461
During an effort to search for more potent growth hormone secretagogues, we discovered a class of compounds of which the best compound 8 was 7-fold more active in vitro than the best compound in the series we revealed before [Tata, J. ...-S.; Butler, B.; Tsou, N.; Leung, K …
During an effort to search for more potent growth hormone secretagogues, we discovered a class of compounds of which the best compoun …
1-[2(R)-(2-amino-2-methylpropionylamino)-3-(1H-indol-3-yl)propionyl]- 3-benzylpiperidine-3(S)-carboxylic acid ethyl ester (L-163,540): a potent, orally bioavailable, and short-duration growth hormone secretagogue.
Yang L, Morriello G, Patchett AA, Leung K, Jacks T, Cheng K, Schleim KD, Feeney W, Chan WW, Chiu SH, Smith RG. Yang L, et al. Among authors: patchett aa. J Med Chem. 1998 Jul 2;41(14):2439-41. doi: 10.1021/jm9800191. J Med Chem. 1998. PMID: 9651148 No abstract available.
141 results