Patchett A - Search Results

1

MK-0677, a potent, novel, orally active growth hormone (GH) secretagogue: GH, insulin-like growth factor I, and other hormonal responses in beagles.

Jacks T, Smith R, Judith F, Schleim K, Frazier E, Chen H, Krupa D, Hora D Jr, Nargund R, Patchett A, Hickey G. Jacks T, et al. Among authors: patchett a. Endocrinology. 1996 Dec;137(12):5284-9. doi: 10.1210/endo.137.12.8940347. Endocrinology. 1996. PMID: 8940347

2

Substituted bridged phenyl piperidines: orally active growth hormone secretagogues.

Lu Z, Tata JR, Cheng K, Wei L, Chan WW, Butler B, Schleim KD, Jacks TM, Hickey G, Patchett AA. Lu Z, et al. Among authors: patchett aa. Bioorg Med Chem Lett. 2003 May 19;13(10):1817-20. doi: 10.1016/s0960-894x(03)00261-0. Bioorg Med Chem Lett. 2003. PMID: 12729672

3

Highly potent growth hormone secretagogues.

Lu Z, Tata JR, Cheng K, Wei L, Chan WW, Butler B, Schleim KD, Jacks TM, Hickey G, Patchett AA. Lu Z, et al. Among authors: patchett aa. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3657-9. doi: 10.1016/j.bmcl.2007.04.050. Epub 2007 Apr 25. Bioorg Med Chem Lett. 2007. PMID: 17482461

During an effort to search for more potent growth hormone secretagogues, we discovered a class of compounds of which the best compound 8 was 7-fold more active in vitro than the best compound in the series we revealed before [Tata, J. ...-S.; Butler, B.; Tsou, N.; Leung, K …

During an effort to search for more potent growth hormone secretagogues, we discovered a class of compounds of which the best compoun …

4

Modulation of pulsatile GH release through a novel receptor in hypothalamus and pituitary gland.

Smith RG, Pong SS, Hickey G, Jacks T, Cheng K, Leonard R, Cohen CJ, Arena JP, Chang CH, Drisko J, Wyvratt M, Fisher M, Nargund R, Patchett A. Smith RG, et al. Among authors: patchett a. Recent Prog Horm Res. 1996;51:261-85; discussion 285-6. Recent Prog Horm Res. 1996. PMID: 8701083 Review.

5

Growth hormone (GH) and insulin-like growth factor I responses after treatments with an orally active GH secretagogue L-163,255 in swine.

Chang CH, Rickes EL, McGuire L, Frazier E, Chen H, Barakat K, Nargund R, Patchett A, Smith RG, Hickey GJ. Chang CH, et al. Among authors: patchett a. Endocrinology. 1996 Nov;137(11):4851-6. doi: 10.1210/endo.137.11.8895356. Endocrinology. 1996. PMID: 8895356

6

Orally active growth hormone secretagogues.

Patchett AA, Smith RG, Wyvratt MJ. Patchett AA, et al. Pharm Biotechnol. 1998;11:525-54. doi: 10.1007/0-306-47384-4_23. Pharm Biotechnol. 1998. PMID: 9760695 Review. No abstract available.

7

Synthesis and biological activities of phenyl piperazine-based peptidomimetic growth hormone secretagogues.

Barakat KJ, Cheng K, Chan WW, Butler BS, Jacks TM, Schleim KD, Hora DF Jr, Hickey GJ, Smith RG, Patchett AA, Nargund RP. Barakat KJ, et al. Among authors: patchett aa. Bioorg Med Chem Lett. 1998 Jun 2;8(11):1431-6. doi: 10.1016/s0960-894x(98)00238-8. Bioorg Med Chem Lett. 1998. PMID: 9871779

8

Potent 3-spiropiperidine growth hormone secretagogues.

Yang L, Morriello G, Prendergast K, Cheng K, Jacks T, Chan WW, Schleim KD, Smith RG, Patchett AA. Yang L, et al. Among authors: patchett aa. Bioorg Med Chem Lett. 1998 Jan 6;8(1):107-12. doi: 10.1016/s0960-894x(97)10199-8. Bioorg Med Chem Lett. 1998. PMID: 9925440

9

Thiazole-derived potent, highly bioavailable short duration growth hormone secretagogues.

Yang L, Morriello G, Leung K, Jacks T, Cheng K, Schleim KD, Smith R, Patchett AA. Yang L, et al. Among authors: patchett aa. Bioorg Med Chem Lett. 1999 Jul 5;9(13):1761-6. doi: 10.1016/s0960-894x(99)00286-3. Bioorg Med Chem Lett. 1999. PMID: 10406638

10

Design and biological activities of L-163,191 (MK-0677): a potent, orally active growth hormone secretagogue.

Patchett AA, Nargund RP, Tata JR, Chen MH, Barakat KJ, Johnston DB, Cheng K, Chan WW, Butler B, Hickey G, et al. Patchett AA, et al. Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):7001-5. doi: 10.1073/pnas.92.15.7001. Proc Natl Acad Sci U S A. 1995. PMID: 7624358 Free PMC article.

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