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Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits.
MacPherson LJ, Bayburt EK, Capparelli MP, Carroll BJ, Goldstein R, Justice MR, Zhu L, Hu S, Melton RA, Fryer L, Goldberg RL, Doughty JR, Spirito S, Blancuzzi V, Wilson D, O'Byrne EM, Ganu V, Parker DT. MacPherson LJ, et al. Among authors: hu s. J Med Chem. 1997 Aug 1;40(16):2525-32. doi: 10.1021/jm960871c. J Med Chem. 1997. PMID: 9258358
Inhibition of interleukin-1alpha-induced cartilage oligomeric matrix protein degradation in bovine articular cartilage by matrix metalloproteinase inhibitors: potential role for matrix metalloproteinases in the generation of cartilage oligomeric matrix protein fragments in arthritic synovial fluid.
Ganu V, Goldberg R, Peppard J, Rediske J, Melton R, Hu SI, Wang W, Duvander C, Heinegård D. Ganu V, et al. Among authors: hu si. Arthritis Rheum. 1998 Dec;41(12):2143-51. doi: 10.1002/1529-0131(199812)41:12<2143::AID-ART9>3.0.CO;2-P. Arthritis Rheum. 1998. PMID: 9870871
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