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Modification of the genetic program of human alveolar macrophages by adenovirus vectors in vitro is feasible but inefficient, limited in part by the low level of expression of the coxsackie/adenovirus receptor.
Kaner RJ, Worgall S, Leopold PL, Stolze E, Milano E, Hidaka C, Ramalingam R, Hackett NR, Singh R, Bergelson J, Finberg R, Falck-Pedersen E, Crystal RG. Kaner RJ, et al. Among authors: leopold pl. Am J Respir Cell Mol Biol. 1999 Mar;20(3):361-70. doi: 10.1165/ajrcmb.20.3.3398. Am J Respir Cell Mol Biol. 1999. PMID: 10030833
Airway epithelial CFTR mRNA expression in cystic fibrosis patients after repetitive administration of a recombinant adenovirus.
Harvey BG, Leopold PL, Hackett NR, Grasso TM, Williams PM, Tucker AL, Kaner RJ, Ferris B, Gonda I, Sweeney TD, Ramalingam R, Kovesdi I, Shak S, Crystal RG. Harvey BG, et al. Among authors: leopold pl. J Clin Invest. 1999 Nov;104(9):1245-55. doi: 10.1172/JCI7935. J Clin Invest. 1999. PMID: 10545523 Free PMC article. Clinical Trial.
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