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Aggrecanase and metalloproteinase-specific aggrecan neo-epitopes are induced in the articular cartilage of mice with collagen II-induced arthritis.
Singer II, Scott S, Kawka DW, Bayne EK, Weidner JR, Williams HR, Mumford RA, Lark MW, McDonnell J, Christen AJ, Moore VL, Mudgett JS, Visco DM. Singer II, et al. Among authors: visco dm. Osteoarthritis Cartilage. 1997 Nov;5(6):407-18. doi: 10.1016/s1063-4584(97)80045-3. Osteoarthritis Cartilage. 1997. PMID: 9536289 Free article.
Inhibition of stromelysin-1 (MMP-3) by P1'-biphenylylethyl carboxyalkyl dipeptides.
Esser CK, Bugianesi RL, Caldwell CG, Chapman KT, Durette PL, Girotra NN, Kopka IE, Lanza TJ, Levorse DA, MacCoss M, Owens KA, Ponpipom MM, Simeone JP, Harrison RK, Niedzwiecki L, Becker JW, Marcy AI, Axel MG, Christen AJ, McDonnell J, Moore VL, Olszewski JM, Saphos C, Visco DM, Hagmann WK, et al. Esser CK, et al. Among authors: visco dm. J Med Chem. 1997 Mar 14;40(6):1026-40. doi: 10.1021/jm960465t. J Med Chem. 1997. PMID: 9083493
Gene deletion of either interleukin-1beta, interleukin-1beta-converting enzyme, inducible nitric oxide synthase, or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament and partial medial meniscectomy.
Clements KM, Price JS, Chambers MG, Visco DM, Poole AR, Mason RM. Clements KM, et al. Among authors: visco dm. Arthritis Rheum. 2003 Dec;48(12):3452-63. doi: 10.1002/art.11355. Arthritis Rheum. 2003. PMID: 14673996 Free article.
Pyrroles and other heterocycles as inhibitors of p38 kinase.
de Laszlo SE, Visco D, Agarwal L, Chang L, Chin J, Croft G, Forsyth A, Fletcher D, Frantz B, Hacker C, Hanlon W, Harper C, Kostura M, Li B, Luell S, MacCoss M, Mantlo N, O'Neill EA, Orevillo C, Pang M, Parsons J, Rolando A, Sahly Y, Sidler K, O'Keefe SJ, et al. de Laszlo SE, et al. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2689-94. doi: 10.1016/s0960-894x(98)00495-8. Bioorg Med Chem Lett. 1998. PMID: 9873604
55 results