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A novel selective progesterone receptor modulator asoprisnil activates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated signaling pathway in cultured human uterine leiomyoma cells in the absence of comparable effects on myometrial cells.
Sasaki H, Ohara N, Xu Q, Wang J, DeManno DA, Chwalisz K, Yoshida S, Maruo T. Sasaki H, et al. Among authors: demanno da. J Clin Endocrinol Metab. 2007 Feb;92(2):616-23. doi: 10.1210/jc.2006-0898. Epub 2006 Nov 14. J Clin Endocrinol Metab. 2007. PMID: 17105846
A novel selective progesterone receptor modulator asoprisnil (J867) inhibits proliferation and induces apoptosis in cultured human uterine leiomyoma cells in the absence of comparable effects on myometrial cells.
Chen W, Ohara N, Wang J, Xu Q, Liu J, Morikawa A, Sasaki H, Yoshida S, Demanno DA, Chwalisz K, Maruo T. Chen W, et al. Among authors: demanno da. J Clin Endocrinol Metab. 2006 Apr;91(4):1296-304. doi: 10.1210/jc.2005-2379. Epub 2006 Feb 7. J Clin Endocrinol Metab. 2006. PMID: 16464945
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