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A potent, orally bioavailable benzazepinone growth hormone secretagogue.
DeVita RJ, Bochis R, Frontier AJ, Kotliar A, Fisher MH, Schoen WR, Wyvratt MJ, Cheng K, Chan WW, Butler B, Jacks TM, Hickey GJ, Schleim KD, Leung K, Chen Z, Chiu SL, Feeney WP, Cunningham PK, Smith RG. DeVita RJ, et al. Among authors: cunningham pk. J Med Chem. 1998 May 7;41(10):1716-28. doi: 10.1021/jm970816j. J Med Chem. 1998. PMID: 9572898
Administration of a nonpeptidyl growth hormone secretagogue, L-163, 255, changes somatostatin pattern, but has no effect on patterns of growth hormone-releasing factor in the hypophyseal-portal circulation of the conscious pig.
Drisko JE, Faidley TD, Zhang D, McDonald TJ, Nicolich S, Hora DF, Cunningham P, Li C, Rickes E, McNamara L, Chang C, Smith RG, Hickey GJ. Drisko JE, et al. Proc Soc Exp Biol Med. 1999 Oct;222(1):70-7. doi: 10.1111/j.1525-1373.1999.09997.x. Proc Soc Exp Biol Med. 1999. PMID: 10510248
Formation of eosinophilic and monocytic intradermal inflammatory sites in the dog by injection of human RANTES but not human monocyte chemoattractant protein 1, human macrophage inflammatory protein 1 alpha, or human interleukin 8.
Meurer R, Van Riper G, Feeney W, Cunningham P, Hora D Jr, Springer MS, MacIntyre DE, Rosen H. Meurer R, et al. J Exp Med. 1993 Dec 1;178(6):1913-21. doi: 10.1084/jem.178.6.1913. J Exp Med. 1993. PMID: 7504053 Free PMC article.
Blockade of the voltage-gated potassium channel Kv1.3 inhibits immune responses in vivo.
Koo GC, Blake JT, Talento A, Nguyen M, Lin S, Sirotina A, Shah K, Mulvany K, Hora D Jr, Cunningham P, Wunderler DL, McManus OB, Slaughter R, Bugianesi R, Felix J, Garcia M, Williamson J, Kaczorowski G, Sigal NH, Springer MS, Feeney W. Koo GC, et al. J Immunol. 1997 Jun 1;158(11):5120-8. J Immunol. 1997. PMID: 9164927
Correolide and derivatives are novel immunosuppressants blocking the lymphocyte Kv1.3 potassium channels.
Koo GC, Blake JT, Shah K, Staruch MJ, Dumont F, Wunderler D, Sanchez M, McManus OB, Sirotina-Meisher A, Fischer P, Boltz RC, Goetz MA, Baker R, Bao J, Kayser F, Rupprecht KM, Parsons WH, Tong XC, Ita IE, Pivnichny J, Vincent S, Cunningham P, Hora D Jr, Feeney W, Kaczorowski G, et al. Koo GC, et al. Cell Immunol. 1999 Nov 1;197(2):99-107. doi: 10.1006/cimm.1999.1569. Cell Immunol. 1999. PMID: 10607427
19 results