DeVita RJ - Search Results

1

A potent, orally bioavailable benzazepinone growth hormone secretagogue.

DeVita RJ, Bochis R, Frontier AJ, Kotliar A, Fisher MH, Schoen WR, Wyvratt MJ, Cheng K, Chan WW, Butler B, Jacks TM, Hickey GJ, Schleim KD, Leung K, Chen Z, Chiu SL, Feeney WP, Cunningham PK, Smith RG. DeVita RJ, et al. J Med Chem. 1998 May 7;41(10):1716-28. doi: 10.1021/jm970816j. J Med Chem. 1998. PMID: 9572898

2

Identification and initial structure-activity relationships of a novel non-peptide quinolone GnRH receptor antagonist.

DeVita RJ, Hollings DD, Goulet MT, Wyvratt MJ, Fisher MH, Lo JL, Yang YT, Cheng K, Smith RG. DeVita RJ, et al. Bioorg Med Chem Lett. 1999 Sep 6;9(17):2615-20. doi: 10.1016/s0960-894x(99)00446-1. Bioorg Med Chem Lett. 1999. PMID: 10498220

3

Investigation of the 4-O-alkylamine substituent of non-peptide quinolone GnRH receptor antagonists.

DeVita RJ, Goulet MT, Wyvratt MJ, Fisher MH, Lo JL, Yang YT, Cheng K, Smith RG. DeVita RJ, et al. Bioorg Med Chem Lett. 1999 Sep 6;9(17):2621-4. doi: 10.1016/s0960-894x(99)00447-3. Bioorg Med Chem Lett. 1999. PMID: 10498221

4

Potent antagonists of gonadotropin releasing hormone receptors derived from quinolone-6-carboxamides.

Walsh TF, Toupence RB, Young JR, Huang SX, Ujjainwalla F, DeVita RJ, Goulet MT, Wyvratt MJ Jr, Fisher MH, Lo JL, Ren N, Yudkovitz JB, Yang YT, Cheng K, Smith RG. Walsh TF, et al. Among authors: devita rj. Bioorg Med Chem Lett. 2000 Mar 6;10(5):443-7. doi: 10.1016/s0960-894x(00)00024-x. Bioorg Med Chem Lett. 2000. PMID: 10743944

5

Quinolones as gonadotropin releasing hormone (GnRH) antagonists: simultaneous optimization of the C(3)-aryl and C(6)-substituents.

Young JR, Huang SX, Chen I, Walsh TF, DeVita RJ, Wyvratt MJ Jr, Goulet MT, Ren N, Lo J, Yang YT, Yudkovitz JB, Cheng K, Smith RG. Young JR, et al. Among authors: devita rj. Bioorg Med Chem Lett. 2000 Aug 7;10(15):1723-7. doi: 10.1016/s0960-894x(00)00318-8. Bioorg Med Chem Lett. 2000. PMID: 10937733

6

A potent, nonpeptidyl 1H-quinolone antagonist for the gonadotropin-releasing hormone receptor.

DeVita RJ, Walsh TF, Young JR, Jiang J, Ujjainwalla F, Toupence RB, Parikh M, Huang SX, Fair JA, Goulet MT, Wyvratt MJ, Lo JL, Ren N, Yudkovitz JB, Yang YT, Cheng K, Cui J, Mount G, Rohrer SP, Schaeffer JM, Rhodes L, Drisko JE, McGowan E, MacIntyre DE, Vincent S, Carlin JR, Cameron J, Smith RG. DeVita RJ, et al. J Med Chem. 2001 Mar 15;44(6):917-22. doi: 10.1021/jm000275p. J Med Chem. 2001. PMID: 11300873

7

Syntheses and structure-activity relationship studies of piperidine-substituted quinolones as nonpeptide gonadotropin releasing hormone antagonists.

Jiang J, DeVita RJ, Goulet MT, Wyvratt MJ, Lo JL, Ren N, Yudkovitz JB, Cui J, Yang YT, Cheng K, Rohrer SP. Jiang J, et al. Among authors: devita rj. Bioorg Med Chem Lett. 2004 Apr 5;14(7):1795-8. doi: 10.1016/j.bmcl.2003.12.101. Bioorg Med Chem Lett. 2004. PMID: 15026074

8

Identification of neutral 4-O-alkyl quinolone nonpeptide GnRH receptor antagonists.

DeVita RJ, Parikh M, Jiang J, Fair JA, Young JR, Walsh TF, Goulet MT, Lo JL, Ren N, Yudkovitz JB, Cui J, Yang YT, Cheng K, Rohrer SP, Wyvratt MJ. DeVita RJ, et al. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5599-603. doi: 10.1016/j.bmcl.2004.08.056. Bioorg Med Chem Lett. 2004. PMID: 15482932

9

Identification of Phe313 of the gonadotropin-releasing hormone (GnRH) receptor as a site critical for the binding of nonpeptide GnRH antagonists.

Cui J, Smith RG, Mount GR, Lo JL, Yu J, Walsh TF, Singh SB, DeVita RJ, Goulet MT, Schaeffer JM, Cheng K. Cui J, et al. Among authors: devita rj. Mol Endocrinol. 2000 May;14(5):671-81. doi: 10.1210/mend.14.5.0464. Mol Endocrinol. 2000. PMID: 10809231

10

The discovery of potent, selective, and orally bioavailable hNK1 antagonists derived from pyrrolidine.

Lin P, Chang L, Devita RJ, Young JR, Eid R, Tong X, Zheng S, Ball RG, Tsou NN, Chicchi GG, Kurtz MM, Tsao KL, Wheeldon A, Carlson EJ, Eng W, Burns HD, Hargreaves RJ, Mills SG. Lin P, et al. Among authors: devita rj. Bioorg Med Chem Lett. 2007 Sep 15;17(18):5191-8. doi: 10.1016/j.bmcl.2007.06.085. Epub 2007 Jul 4. Bioorg Med Chem Lett. 2007. PMID: 17637506

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