Leung K - Search Results

1

A potent, orally bioavailable benzazepinone growth hormone secretagogue.

DeVita RJ, Bochis R, Frontier AJ, Kotliar A, Fisher MH, Schoen WR, Wyvratt MJ, Cheng K, Chan WW, Butler B, Jacks TM, Hickey GJ, Schleim KD, Leung K, Chen Z, Chiu SL, Feeney WP, Cunningham PK, Smith RG. DeVita RJ, et al. Among authors: leung k. J Med Chem. 1998 May 7;41(10):1716-28. doi: 10.1021/jm970816j. J Med Chem. 1998. PMID: 9572898

2

1-[2(R)-(2-amino-2-methylpropionylamino)-3-(1H-indol-3-yl)propionyl]- 3-benzylpiperidine-3(S)-carboxylic acid ethyl ester (L-163,540): a potent, orally bioavailable, and short-duration growth hormone secretagogue.

Yang L, Morriello G, Patchett AA, Leung K, Jacks T, Cheng K, Schleim KD, Feeney W, Chan WW, Chiu SH, Smith RG. Yang L, et al. Among authors: leung k. J Med Chem. 1998 Jul 2;41(14):2439-41. doi: 10.1021/jm9800191. J Med Chem. 1998. PMID: 9651148 No abstract available.

3

Thiazole-derived potent, highly bioavailable short duration growth hormone secretagogues.

Yang L, Morriello G, Leung K, Jacks T, Cheng K, Schleim KD, Smith R, Patchett AA. Yang L, et al. Among authors: leung k. Bioorg Med Chem Lett. 1999 Jul 5;9(13):1761-6. doi: 10.1016/s0960-894x(99)00286-3. Bioorg Med Chem Lett. 1999. PMID: 10406638

4

Pharmacokinetics and disposition of L-692,429. A novel nonpeptidyl growth hormone secretagogue in preclinical species.

Leung KH, Cohn DA, Miller RR, Doss GA, Stearns RA, Simpson RE, Feeney WP, Chiu SH. Leung KH, et al. Drug Metab Dispos. 1996 Jul;24(7):753-60. Drug Metab Dispos. 1996. PMID: 8818572

5

In vitro and in vivo trans-esterification of 1-[2(R)-(2-amino-2-methylpropionylamino)-3-(1H-indol-3-yl)propionyl]-3(S)-benzyl-piperidine-3-carboxylic acid ethyl ester and the effects of ethanol on its pharmacokinetics in rats.

Chen Z, Agrawal AK, Franklin RB, Leung KH, Chiu SH. Chen Z, et al. Among authors: leung kh. Pharm Res. 2004 Jun;21(6):996-9. doi: 10.1023/b:pham.0000029289.95033.b9. Pharm Res. 2004. PMID: 15212165

6

A simple in vitro model to study the stability of acylglucuronides.

Chen Z, Holt TG, Pivnichny JV, Leung K. Chen Z, et al. Among authors: leung k. J Pharmacol Toxicol Methods. 2007 Jan-Feb;55(1):91-5. doi: 10.1016/j.vascn.2006.03.008. Epub 2006 Apr 5. J Pharmacol Toxicol Methods. 2007. PMID: 16713308

7

Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites.

Tang W, Stearns RA, Bandiera SM, Zhang Y, Raab C, Braun MP, Dean DC, Pang J, Leung KH, Doss GA, Strauss JR, Kwei GY, Rushmore TH, Chiu SH, Baillie TA. Tang W, et al. Among authors: leung kh. Drug Metab Dispos. 1999 Mar;27(3):365-72. Drug Metab Dispos. 1999. PMID: 10064567

8

Determination of in vitro permeability of drug candidates through a caco-2 cell monolayer by liquid chromatography/tandem mass spectrometry.

Wang Z, Hop CE, Leung KH, Pang J. Wang Z, et al. Among authors: leung kh. J Mass Spectrom. 2000 Jan;35(1):71-6. doi: 10.1002/(SICI)1096-9888(200001)35:1<71::AID-JMS915>3.0.CO;2-5. J Mass Spectrom. 2000. PMID: 10633236

9

Evidence for a novel heme adduct generated by the in vitro reaction of 2,4,6-trinitrotoluene with human hemoglobin using electrospray ionization mass spectrometry.

Bakhtiar R, Leung KH, Stearns RA, Hop CE. Bakhtiar R, et al. Among authors: leung kh. J Inorg Biochem. 1997 Dec;68(4):273-8. doi: 10.1016/s0162-0134(97)00108-6. J Inorg Biochem. 1997. PMID: 9397575

10

Mechanism of bioactivation and covalent binding of 2,4,6-trinitrotoluene.

Leung KH, Yao M, Stearns R, Chiu SH. Leung KH, et al. Chem Biol Interact. 1995 Jun 30;97(1):37-51. doi: 10.1016/0009-2797(94)03606-9. Chem Biol Interact. 1995. PMID: 7767940

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