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Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction.
Lygate CA, Bohl S, ten Hove M, Faller KM, Ostrowski PJ, Zervou S, Medway DJ, Aksentijevic D, Sebag-Montefiore L, Wallis J, Clarke K, Watkins H, Schneider JE, Neubauer S. Lygate CA, et al. Among authors: sebag montefiore l. Cardiovasc Res. 2012 Dec 1;96(3):466-75. doi: 10.1093/cvr/cvs272. Epub 2012 Aug 21. Cardiovasc Res. 2012. PMID: 22915766 Free PMC article.
Supranormal myocardial creatine and phosphocreatine concentrations lead to cardiac hypertrophy and heart failure: insights from creatine transporter-overexpressing transgenic mice.
Wallis J, Lygate CA, Fischer A, ten Hove M, Schneider JE, Sebag-Montefiore L, Dawson D, Hulbert K, Zhang W, Zhang MH, Watkins H, Clarke K, Neubauer S. Wallis J, et al. Circulation. 2005 Nov 15;112(20):3131-9. doi: 10.1161/CIRCULATIONAHA.105.572990. Circulation. 2005. PMID: 16286605
Mice over-expressing the myocardial creatine transporter develop progressive heart failure and show decreased glycolytic capacity.
Phillips D, Ten Hove M, Schneider JE, Wu CO, Sebag-Montefiore L, Aponte AM, Lygate CA, Wallis J, Clarke K, Watkins H, Balaban RS, Neubauer S. Phillips D, et al. Among authors: sebag montefiore l. J Mol Cell Cardiol. 2010 Apr;48(4):582-90. doi: 10.1016/j.yjmcc.2009.10.033. Epub 2009 Nov 11. J Mol Cell Cardiol. 2010. PMID: 19913546 Free PMC article.
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